2806. The Mechanism of β-Lactam Antibiotic Action: Structural Analysis of Mycobacterium abscessus l,d-Transpeptidases, d,d-Carboxypeptidase and penicillin-binding-proteins binding by imipenem, ceftaroline, and amoxicillin

BACKGROUND: M. abscessus (Mab) is among the most clinically challenging pathogens. There are significant gaps remaining in mechanism of β-lactams action in Mab. β-Lactams preferentially inactivate one or multiple different L,D-Transpeptidases (LDTs) and penicillin-binding proteins (PBPs). Founded on...

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Detalles Bibliográficos
Autores principales: Shin, Eunjeong, Nantongo, Mary, Dousa, Khalid M, Bethel, Christopher R, Taracila, Magdalena A, Kreiswirth, Barry N, Holland, Steven M, Bonomo, Robert A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677597/
http://dx.doi.org/10.1093/ofid/ofad500.2417

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