250. Single cell profiling of blood immune cell kinetics in early sepsis reveals progressive decrease in a monocyte substate with immunosuppressive activity

BACKGROUND: Dysregulation of the immune response to bacterial infection is an essential but poorly understood component of sepsis. Kinetic changes in immune cell quantity during sepsis can reveal key elements of immunopathogenesis, yet these data are scant. Single-cell RNA sequencing (scRNA-seq) of...

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Detalles Bibliográficos
Autores principales: Ankomah, Pierre, DuBois, Alyssa, Sonny, Abraham, Filbin, Michael, Goldberg, Marcia B, Blainey, Paul, Hacohen, Nir, Bhattacharyya, Roby P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677682/
http://dx.doi.org/10.1093/ofid/ofad500.323

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