Cargando…
1746. RSV seasonality patterns change during 2016 to 2020 among hospitalized young children in Taiwan
BACKGROUND: Respiratory syncytial virus (RSV) is a common cause of hospitalizations in young children. Previous studies in Taiwan demonstrated seasonality of RSV hospitalization (RSVH) in young children was rather year-round with small peaks in spring and fall. This study aims to investigate recent...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677851/ http://dx.doi.org/10.1093/ofid/ofad500.1577 |
_version_ | 1785150227419758592 |
---|---|
author | Chung, Ching-Hu Tsai, Szu-Ying Yeh, Ting-Yu |
author_facet | Chung, Ching-Hu Tsai, Szu-Ying Yeh, Ting-Yu |
author_sort | Chung, Ching-Hu |
collection | PubMed |
description | BACKGROUND: Respiratory syncytial virus (RSV) is a common cause of hospitalizations in young children. Previous studies in Taiwan demonstrated seasonality of RSV hospitalization (RSVH) in young children was rather year-round with small peaks in spring and fall. This study aims to investigate recent seasonality patterns of RSVH in Taiwan using latest National Health Insurance (NHI) database. METHODS: We linked Taiwan birth cohort database to the NHI database for the years 2016-2020. Children < 5 years having hospital admission record with RSV ICD-10 coding were defined as having RSVH. To assess the correlations between RSVH with monthly average temperature/humidity, we used data from 2016-2019 (not including 2020 due to unusual RSV endemic) and by geographic region (Northern, Central, and Southern Taiwan). RESULTS: In children < 1 year, the annual RSVH incidence increased steadily from 1.32% in 2016, 1.55% in 2017, 1.60% in 2018, 1.67% in 2019, to 1.71% in 2020 (p=0.03). In contrast, for children aged 1-4 years, the annual RSVH incidence remained somewhat stable from 0.29%, 0.33%, 0.36%, 0.31% from 2016 to 2019, then substantially increased to 0.76% in 2020 (a 2.47-fold increase compared to 2019, p=0.22). Only one RSVH peak was observed per year for both age groups: in May for 2016, September for 2017-2019 and November for 2020. Temperature and RSVH showed high correlation among years 2016-2019, with correlation coefficients 0.64-0.68 and 0.64-0.66 in children aged < 1 and 1-4 years, respectively. However, RSVH only showed low to moderate correlation with humidity in both age groups. CONCLUSION: The previously established seasonality patterns of RSVH in Taiwan were disrupted. A higher RSVH incidence for children aged 1-4 years was noted during 2020 endemic than previous years. Only one RSVH peak was observed in 2016-2020, and its correlation with temperature was high. DISCLOSURES: Ching-Hu Chung, PhD, Sanofi and AstraZeneca: Grant/Research Support Szu-Ying Tsai, n/a, Sanofi: employe Ting-Yu Yeh, n/a, Sanofi: employe |
format | Online Article Text |
id | pubmed-10677851 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-106778512023-11-27 1746. RSV seasonality patterns change during 2016 to 2020 among hospitalized young children in Taiwan Chung, Ching-Hu Tsai, Szu-Ying Yeh, Ting-Yu Open Forum Infect Dis Abstract BACKGROUND: Respiratory syncytial virus (RSV) is a common cause of hospitalizations in young children. Previous studies in Taiwan demonstrated seasonality of RSV hospitalization (RSVH) in young children was rather year-round with small peaks in spring and fall. This study aims to investigate recent seasonality patterns of RSVH in Taiwan using latest National Health Insurance (NHI) database. METHODS: We linked Taiwan birth cohort database to the NHI database for the years 2016-2020. Children < 5 years having hospital admission record with RSV ICD-10 coding were defined as having RSVH. To assess the correlations between RSVH with monthly average temperature/humidity, we used data from 2016-2019 (not including 2020 due to unusual RSV endemic) and by geographic region (Northern, Central, and Southern Taiwan). RESULTS: In children < 1 year, the annual RSVH incidence increased steadily from 1.32% in 2016, 1.55% in 2017, 1.60% in 2018, 1.67% in 2019, to 1.71% in 2020 (p=0.03). In contrast, for children aged 1-4 years, the annual RSVH incidence remained somewhat stable from 0.29%, 0.33%, 0.36%, 0.31% from 2016 to 2019, then substantially increased to 0.76% in 2020 (a 2.47-fold increase compared to 2019, p=0.22). Only one RSVH peak was observed per year for both age groups: in May for 2016, September for 2017-2019 and November for 2020. Temperature and RSVH showed high correlation among years 2016-2019, with correlation coefficients 0.64-0.68 and 0.64-0.66 in children aged < 1 and 1-4 years, respectively. However, RSVH only showed low to moderate correlation with humidity in both age groups. CONCLUSION: The previously established seasonality patterns of RSVH in Taiwan were disrupted. A higher RSVH incidence for children aged 1-4 years was noted during 2020 endemic than previous years. Only one RSVH peak was observed in 2016-2020, and its correlation with temperature was high. DISCLOSURES: Ching-Hu Chung, PhD, Sanofi and AstraZeneca: Grant/Research Support Szu-Ying Tsai, n/a, Sanofi: employe Ting-Yu Yeh, n/a, Sanofi: employe Oxford University Press 2023-11-27 /pmc/articles/PMC10677851/ http://dx.doi.org/10.1093/ofid/ofad500.1577 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Chung, Ching-Hu Tsai, Szu-Ying Yeh, Ting-Yu 1746. RSV seasonality patterns change during 2016 to 2020 among hospitalized young children in Taiwan |
title | 1746. RSV seasonality patterns change during 2016 to 2020 among hospitalized young children in Taiwan |
title_full | 1746. RSV seasonality patterns change during 2016 to 2020 among hospitalized young children in Taiwan |
title_fullStr | 1746. RSV seasonality patterns change during 2016 to 2020 among hospitalized young children in Taiwan |
title_full_unstemmed | 1746. RSV seasonality patterns change during 2016 to 2020 among hospitalized young children in Taiwan |
title_short | 1746. RSV seasonality patterns change during 2016 to 2020 among hospitalized young children in Taiwan |
title_sort | 1746. rsv seasonality patterns change during 2016 to 2020 among hospitalized young children in taiwan |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677851/ http://dx.doi.org/10.1093/ofid/ofad500.1577 |
work_keys_str_mv | AT chungchinghu 1746rsvseasonalitypatternschangeduring2016to2020amonghospitalizedyoungchildrenintaiwan AT tsaiszuying 1746rsvseasonalitypatternschangeduring2016to2020amonghospitalizedyoungchildrenintaiwan AT yehtingyu 1746rsvseasonalitypatternschangeduring2016to2020amonghospitalizedyoungchildrenintaiwan |