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2385. Factors associated with delay of completion of a two-dose COVID-19 vaccine primary series among servicemembers in the Military Health System

BACKGROUND: Efficacy of a two-dose COVID-19 vaccine series at preventing infection is ∼50-80% after the first dose and ∼95% following the second, if completed on the recommended schedule. Although >90% of active-duty servicemembers (SM) completed a primary series, understanding timing of doses as...

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Autores principales: Sercy, Erica, Stewart, Laveta, Craig-Kuhn, Megan Clare, Stern, Caryn, Graham, Brock, Michel, Amber, Parmelee, Edward, Shackelford, Stacy, Pollett, Simon, Burgess, Timothy, Tribble, David R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677916/
http://dx.doi.org/10.1093/ofid/ofad500.2005
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author Sercy, Erica
Stewart, Laveta
Craig-Kuhn, Megan Clare
Stern, Caryn
Graham, Brock
Michel, Amber
Parmelee, Edward
Shackelford, Stacy
Pollett, Simon
Burgess, Timothy
Tribble, David R
Tribble, David R
author_facet Sercy, Erica
Stewart, Laveta
Craig-Kuhn, Megan Clare
Stern, Caryn
Graham, Brock
Michel, Amber
Parmelee, Edward
Shackelford, Stacy
Pollett, Simon
Burgess, Timothy
Tribble, David R
Tribble, David R
author_sort Sercy, Erica
collection PubMed
description BACKGROUND: Efficacy of a two-dose COVID-19 vaccine series at preventing infection is ∼50-80% after the first dose and ∼95% following the second, if completed on the recommended schedule. Although >90% of active-duty servicemembers (SM) completed a primary series, understanding timing of doses as recommended among Military Health System (MHS) beneficiaries is vital to prevent COVID-19 outbreaks. [Figure: see text] METHODS: Active-duty and National Guard/Reserve on active-duty SM aged ≥17 years who were beneficiaries of the MHS during 1/1/2020-6/30/2022 and completed a two-dose primary series were assessed for timing of the vaccines (stratified as early, grace period, recommended, and late) and associated demographic factors. SARS-CoV-2 infection (laboratory confirmed or ICD-10 diagnosis) prior to initiating the primary series, between the two doses, or after completion of the primary series was also assessed. Descriptive statistics (chi-square) were used to identify associations with timing of the second primary dose. RESULTS: Among 1,426,436 SM, 97.9% were aged 17-49, 81.4% were male, 69.8% were white, and 35.6% served in the Army (Table 1). Overall, 92.7% received their second primary dose in the recommended or grace periods, and 7.3% were late. Timing of the first and second vaccine doses showed peaks in the months following the vaccine EUA, as well as after the DoD vaccine mandate. SM who had a COVID diagnosis between their two primary doses were more likely to receive a late second dose, although the diagnosis was likely not the cause for the late second dose, as were those who received their first dose during the pre-mandate period. SM receiving a late second dose were more likely to be younger, in the Air Force or Army, and reside in HHS regions 4, 5, 6, 7, and 8. [Figure: see text] CONCLUSION: Most of the population received their second primary dose on the recommended schedule or earlier. However, SM in the Air Force and Army were more likely to receive their second dose later than recommended, as were those who lived in the South, West, and Midwest and those who had COVID-19 infection between their primary doses. Future research will investigate adverse disease outcomes associated with a delayed second dose in the primary series, as well as potential interactions between factors predicting delayed second dose uptake. DISCLOSURES: Simon Pollett, MBBS, AstraZeneca: The IDCRP and the Henry M. Jackson Foundation (HJF) were funded to conduct an unrelated phase III COVID-19 monoclonal antibody immunoprophylaxis trial Timothy Burgess, MD, MPH, AstraZeneca: The IDCRP and the Henry M. Jackson Foundation (HJF) were funded to conduct an unrelated phase III COVID-19 monoclonal antibody immunoprophylaxis trial
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spelling pubmed-106779162023-11-27 2385. Factors associated with delay of completion of a two-dose COVID-19 vaccine primary series among servicemembers in the Military Health System Sercy, Erica Stewart, Laveta Craig-Kuhn, Megan Clare Stern, Caryn Graham, Brock Michel, Amber Parmelee, Edward Shackelford, Stacy Pollett, Simon Burgess, Timothy Tribble, David R Tribble, David R Open Forum Infect Dis Abstract BACKGROUND: Efficacy of a two-dose COVID-19 vaccine series at preventing infection is ∼50-80% after the first dose and ∼95% following the second, if completed on the recommended schedule. Although >90% of active-duty servicemembers (SM) completed a primary series, understanding timing of doses as recommended among Military Health System (MHS) beneficiaries is vital to prevent COVID-19 outbreaks. [Figure: see text] METHODS: Active-duty and National Guard/Reserve on active-duty SM aged ≥17 years who were beneficiaries of the MHS during 1/1/2020-6/30/2022 and completed a two-dose primary series were assessed for timing of the vaccines (stratified as early, grace period, recommended, and late) and associated demographic factors. SARS-CoV-2 infection (laboratory confirmed or ICD-10 diagnosis) prior to initiating the primary series, between the two doses, or after completion of the primary series was also assessed. Descriptive statistics (chi-square) were used to identify associations with timing of the second primary dose. RESULTS: Among 1,426,436 SM, 97.9% were aged 17-49, 81.4% were male, 69.8% were white, and 35.6% served in the Army (Table 1). Overall, 92.7% received their second primary dose in the recommended or grace periods, and 7.3% were late. Timing of the first and second vaccine doses showed peaks in the months following the vaccine EUA, as well as after the DoD vaccine mandate. SM who had a COVID diagnosis between their two primary doses were more likely to receive a late second dose, although the diagnosis was likely not the cause for the late second dose, as were those who received their first dose during the pre-mandate period. SM receiving a late second dose were more likely to be younger, in the Air Force or Army, and reside in HHS regions 4, 5, 6, 7, and 8. [Figure: see text] CONCLUSION: Most of the population received their second primary dose on the recommended schedule or earlier. However, SM in the Air Force and Army were more likely to receive their second dose later than recommended, as were those who lived in the South, West, and Midwest and those who had COVID-19 infection between their primary doses. Future research will investigate adverse disease outcomes associated with a delayed second dose in the primary series, as well as potential interactions between factors predicting delayed second dose uptake. DISCLOSURES: Simon Pollett, MBBS, AstraZeneca: The IDCRP and the Henry M. Jackson Foundation (HJF) were funded to conduct an unrelated phase III COVID-19 monoclonal antibody immunoprophylaxis trial Timothy Burgess, MD, MPH, AstraZeneca: The IDCRP and the Henry M. Jackson Foundation (HJF) were funded to conduct an unrelated phase III COVID-19 monoclonal antibody immunoprophylaxis trial Oxford University Press 2023-11-27 /pmc/articles/PMC10677916/ http://dx.doi.org/10.1093/ofid/ofad500.2005 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Sercy, Erica
Stewart, Laveta
Craig-Kuhn, Megan Clare
Stern, Caryn
Graham, Brock
Michel, Amber
Parmelee, Edward
Shackelford, Stacy
Pollett, Simon
Burgess, Timothy
Tribble, David R
Tribble, David R
2385. Factors associated with delay of completion of a two-dose COVID-19 vaccine primary series among servicemembers in the Military Health System
title 2385. Factors associated with delay of completion of a two-dose COVID-19 vaccine primary series among servicemembers in the Military Health System
title_full 2385. Factors associated with delay of completion of a two-dose COVID-19 vaccine primary series among servicemembers in the Military Health System
title_fullStr 2385. Factors associated with delay of completion of a two-dose COVID-19 vaccine primary series among servicemembers in the Military Health System
title_full_unstemmed 2385. Factors associated with delay of completion of a two-dose COVID-19 vaccine primary series among servicemembers in the Military Health System
title_short 2385. Factors associated with delay of completion of a two-dose COVID-19 vaccine primary series among servicemembers in the Military Health System
title_sort 2385. factors associated with delay of completion of a two-dose covid-19 vaccine primary series among servicemembers in the military health system
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677916/
http://dx.doi.org/10.1093/ofid/ofad500.2005
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