2518. Lead optimization on 26-membered thiopeptide antibiotics and identification of pre-clinical candidates against Clostridioides difficile and Staphylococcus aureus for impetigo

BACKGROUND: Thiopeptides are structurally complex natural products that exert potent antimicrobial activity against Gram-positive pathogens by inhibiting bacterial protein synthesis. However, there has not been any attempt to conduct extensive medicinal chemistry campaign on these natural products,...

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Detalles Bibliográficos
Autores principales: Hwang, Hee-Jong, Son, Young-Jin, Kim, Dahyun, Lee, Jusuk, Shyaka, Clovis, Kwak, Jin-Hwan, Pai, Hyunjoo, Rho, Mina, Park, Jong-Hwan, Kim, Young-Rok, Jung, Sungji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677983/
http://dx.doi.org/10.1093/ofid/ofad500.2136

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