2556. A Phase 1, Open-Label, Single Dose Study to Evaluate the Pharmacokinetics (PK), Safety, and Tolerability of Epetraborole Tablets and the Impact of Alcohol Dehydrogenase (ADH) Genotype on the PK of Epetraborole and Metabolite M3 in Healthy Japanese Adult Subjects

BACKGROUND: Epetraborole (EBO), an orally available bacterial leucyl transfer RNA synthetase inhibitor with potent activity against nontuberculous mycobacteria, is under clinical development for treatment-refractory MAC lung disease. Nonclinical studies suggest that metabolism of EBO to metabolite M...

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Detalles Bibliográficos
Autores principales: Patel, Gina, Castañeda-Ruiz, Bibiana, Yoshihara, Tatsuya, Krause, Kevin M, O’Shea, Kevin, Kammerer, Linda, Maier, Gary, Long, Jennifer, Smith, Alex, Chanda, Sanjay, Moore, Stephanie, Eckburg, Paul B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677986/
http://dx.doi.org/10.1093/ofid/ofad500.2173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10677986/
http://dx.doi.org/10.1093/ofid/ofad500.2173

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