1350. Solid Organ Transplantation From COVID Positive Donors: Trends in Utilization, Discard & Long-term Outcomes in the United States

BACKGROUND: Transplantation of organs from COVID positive (COVID+) donors is increasing. The aim of this study was to assess the trends in utilization, discard, and longer-term outcomes in solid organ transplant (SOT) recipients who received organs from COVID+ donors in the United States (US). METHO...

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Detalles Bibliográficos
Autores principales: Dhand, Abhay, Okumura, Kenji, Ohira, Suguru, Lansman, Steven, Nishida, Seigo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678080/
http://dx.doi.org/10.1093/ofid/ofad500.1187
Descripción
Sumario:BACKGROUND: Transplantation of organs from COVID positive (COVID+) donors is increasing. The aim of this study was to assess the trends in utilization, discard, and longer-term outcomes in solid organ transplant (SOT) recipients who received organs from COVID+ donors in the United States (US). METHODS: Rates of utilization, discard, and outcomes of SOT from deceased donors with a positive COVID PCR test from respiratory tract between March 2020 and December 2022 were analyzed using the de-identified United Network for Organ Sharing (UNOS) database. RESULTS: During the study period, 1185 COVID+ donors led to the transplantation of 1249 kidneys, 592 livers, and 168 hearts. The center-wise acceptance rate for organs from COVID+ donors increased from 2021 to 2022: heart from 31% to 73%, kidney from 53% to 88%, and liver from 53% to 89%. Discard rates of kidneys from COVID+ donors remained high: left kidney- 29%, right kidney- 32% and were significantly higher than kidney discard rates for COVID negative (COVID-) donors (p < 0.001) When compared to COVID- donors, COVID+ donors were younger and had a lower median Kidney Donor Profile Index (0.51 vs. 0.54, p = .004), lower median serum creatinine (0.9 vs. 1.05 mg/dl, p< 0.001), similar median serum total bilirubin (0.6 mg/dl, p = .15), and similar left ventricular ejection fraction (60%, p = .84). Six months, one-year and 18-month overall and graft survival were comparable between recipients of COVID+ and COVID- donors (table 1) (figures 1). [Figure: see text] Graft Survival: COVID+ vs. COVID- donors [Figure: see text] CONCLUSION: Utilization of organs from COVID+ donors has improved across various transplant centers in the US. Kidney discard rate from COVID+ donors remain high. Longer-term outcomes of SOT from COVID+ donors are encouraging and are helping to successfully expand the donor pool. DISCLOSURES: All Authors: No reported disclosures

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