Cargando…

1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years

BACKGROUND: Endemic coronaviruses (“CoVs”) OC43, HKU1, NL63 and 229E are “common cold viruses” related to SARS-CoV-2, but their natural histories are poorly understood. We documented endemic CoV infections in a prospective cohort of US infants and children to determine the extent to which natural in...

Descripción completa

Detalles Bibliográficos
Autores principales: Payne, Daniel C, Morrow, Ardythe L, Conrey, Shannon C, McMorrow, Meredith L, McNeal, Monica, Niu, Liang, Burrell, Allison, Schlaudecker, Elizabeth P, Mattison, Claire, Burke, Rachel M, DeFranco, Emily A, Teoh, Zheyi, Wrammert, Jens, Atherton, Lydia J, Thornburg, Natalie J, Staat, Mary A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678127/
http://dx.doi.org/10.1093/ofid/ofad500.076
_version_ 1785150291918716928
author Payne, Daniel C
Morrow, Ardythe L
Conrey, Shannon C
McMorrow, Meredith L
McNeal, Monica
Niu, Liang
Burrell, Allison
Schlaudecker, Elizabeth P
Mattison, Claire
Burke, Rachel M
DeFranco, Emily A
Teoh, Zheyi
Wrammert, Jens
Atherton, Lydia J
Thornburg, Natalie J
Staat, Mary A
author_facet Payne, Daniel C
Morrow, Ardythe L
Conrey, Shannon C
McMorrow, Meredith L
McNeal, Monica
Niu, Liang
Burrell, Allison
Schlaudecker, Elizabeth P
Mattison, Claire
Burke, Rachel M
DeFranco, Emily A
Teoh, Zheyi
Wrammert, Jens
Atherton, Lydia J
Thornburg, Natalie J
Staat, Mary A
author_sort Payne, Daniel C
collection PubMed
description BACKGROUND: Endemic coronaviruses (“CoVs”) OC43, HKU1, NL63 and 229E are “common cold viruses” related to SARS-CoV-2, but their natural histories are poorly understood. We documented endemic CoV infections in a prospective cohort of US infants and children to determine the extent to which natural infection protects against subsequent homotypic and heterotypic endemic CoV infections and SARS-CoV-2 infections. METHODS: Cincinnati mother-child pairs were enrolled in the third trimester of pregnancy in 2017-18 and children were followed from birth to 4 years with weekly collection of mid-turbinate nasal swabs. Blood was collected at 6 weeks; 6, 12, 18, 24 months; and annually thereafter. Mothers reported on socio demographics, risk factors, and the child’s weekly symptoms. Medical visits were documented from pediatric care providers. CoV infections were followed for the first 4 years of life (focusing on the most compliant subset of 116 children having >70% weekly sample collection). Infections were identified through nasal swabs tested using a RT-PCR multiplex pathogen panel, and by serum IgG responses using a validated kit at CDC and interpreted using classification and regression tree (CART) analysis. RESULTS: We detected 398 endemic CoV infections over 317.5 child-years of follow-up (1.1 infections/child-year). Endemic beta-coronaviruses, OC43 and HKU1, were associated with statistically significant homotypic protection (77% and 84%, respectively) after a single infection. Similarly protective homotypic associations (73%) were elicited by NL63, the dominant alpha-coronavirus, after two infections. 229E infections were uncommon. No heterotypic protective association was found for any of the endemic CoVs or for SARS-CoV-2 infections from June 2020 to Nov 2021. The majority of endemic CoVs and SARS-CoV-2 infections were asymptomatic, but this proportion varied by CoV strain. Symptomatic infections were mild for all CoV strains with no hospitalizations. CONCLUSION: Natural infection resulted in homotypic immunity but not heterotypic immunity against other CoVs to the 4(th) birthday. Children were not protected against SARS-CoV-2 by prior endemic CoV infections. CoV infections in these young children were largely asymptomatic or mild. DISCLOSURES: Elizabeth P. Schlaudecker, MD, MPH, Pfizer: Grant/Research Support|Sanofi Pasteur: Advisor/Consultant Mary A. Staat, MD, MPH, CDC: Grant/Research Support|Cepheid: Grant/Research Support|Merck: Grant/Research Support|NIH: Grant/Research Support|Pfizer: Grant/Research Support|Up-To-Date: Honoraria
format Online
Article
Text
id pubmed-10678127
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-106781272023-11-27 1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years Payne, Daniel C Morrow, Ardythe L Conrey, Shannon C McMorrow, Meredith L McNeal, Monica Niu, Liang Burrell, Allison Schlaudecker, Elizabeth P Mattison, Claire Burke, Rachel M DeFranco, Emily A Teoh, Zheyi Wrammert, Jens Atherton, Lydia J Thornburg, Natalie J Staat, Mary A Open Forum Infect Dis Abstract BACKGROUND: Endemic coronaviruses (“CoVs”) OC43, HKU1, NL63 and 229E are “common cold viruses” related to SARS-CoV-2, but their natural histories are poorly understood. We documented endemic CoV infections in a prospective cohort of US infants and children to determine the extent to which natural infection protects against subsequent homotypic and heterotypic endemic CoV infections and SARS-CoV-2 infections. METHODS: Cincinnati mother-child pairs were enrolled in the third trimester of pregnancy in 2017-18 and children were followed from birth to 4 years with weekly collection of mid-turbinate nasal swabs. Blood was collected at 6 weeks; 6, 12, 18, 24 months; and annually thereafter. Mothers reported on socio demographics, risk factors, and the child’s weekly symptoms. Medical visits were documented from pediatric care providers. CoV infections were followed for the first 4 years of life (focusing on the most compliant subset of 116 children having >70% weekly sample collection). Infections were identified through nasal swabs tested using a RT-PCR multiplex pathogen panel, and by serum IgG responses using a validated kit at CDC and interpreted using classification and regression tree (CART) analysis. RESULTS: We detected 398 endemic CoV infections over 317.5 child-years of follow-up (1.1 infections/child-year). Endemic beta-coronaviruses, OC43 and HKU1, were associated with statistically significant homotypic protection (77% and 84%, respectively) after a single infection. Similarly protective homotypic associations (73%) were elicited by NL63, the dominant alpha-coronavirus, after two infections. 229E infections were uncommon. No heterotypic protective association was found for any of the endemic CoVs or for SARS-CoV-2 infections from June 2020 to Nov 2021. The majority of endemic CoVs and SARS-CoV-2 infections were asymptomatic, but this proportion varied by CoV strain. Symptomatic infections were mild for all CoV strains with no hospitalizations. CONCLUSION: Natural infection resulted in homotypic immunity but not heterotypic immunity against other CoVs to the 4(th) birthday. Children were not protected against SARS-CoV-2 by prior endemic CoV infections. CoV infections in these young children were largely asymptomatic or mild. DISCLOSURES: Elizabeth P. Schlaudecker, MD, MPH, Pfizer: Grant/Research Support|Sanofi Pasteur: Advisor/Consultant Mary A. Staat, MD, MPH, CDC: Grant/Research Support|Cepheid: Grant/Research Support|Merck: Grant/Research Support|NIH: Grant/Research Support|Pfizer: Grant/Research Support|Up-To-Date: Honoraria Oxford University Press 2023-11-27 /pmc/articles/PMC10678127/ http://dx.doi.org/10.1093/ofid/ofad500.076 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Payne, Daniel C
Morrow, Ardythe L
Conrey, Shannon C
McMorrow, Meredith L
McNeal, Monica
Niu, Liang
Burrell, Allison
Schlaudecker, Elizabeth P
Mattison, Claire
Burke, Rachel M
DeFranco, Emily A
Teoh, Zheyi
Wrammert, Jens
Atherton, Lydia J
Thornburg, Natalie J
Staat, Mary A
1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years
title 1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years
title_full 1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years
title_fullStr 1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years
title_full_unstemmed 1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years
title_short 1103. Endemic Coronavirus Infections in a US Cohort of Children from Birth to 4 Years
title_sort 1103. endemic coronavirus infections in a us cohort of children from birth to 4 years
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678127/
http://dx.doi.org/10.1093/ofid/ofad500.076
work_keys_str_mv AT paynedanielc 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT morrowardythel 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT conreyshannonc 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT mcmorrowmeredithl 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT mcnealmonica 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT niuliang 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT burrellallison 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT schlaudeckerelizabethp 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT mattisonclaire 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT burkerachelm 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT defrancoemilya 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT teohzheyi 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT wrammertjens 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT athertonlydiaj 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT thornburgnataliej 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years
AT staatmarya 1103endemiccoronavirusinfectionsinauscohortofchildrenfrombirthto4years