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1547. Integrating Long-acting Injectable Cabotegravir for PrEP into Standard of Care for Cisgender Women, Transgender Women, Transgender Men, and Men Who Have Sex with Men: Results from the PILLAR & EBONI Studies

BACKGROUND: EBONI and PILLAR are Phase IV implementation science trials evaluating the integration of long-acting injectable Cabotegravir for PrEP (CAB LA) into standard of care at 37 clinics across the U.S. EBONI enrolls Black cisgender/transgender women and PILLAR enrolls men who have sex with men...

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Autores principales: Valenti, William M, Phoenix, John, Patel, Rupa R, Tims-Cook, Zandraetta, Pilgrim, Nanlesta, Haley, Amber, Sutton, Kenneth, Gaudion, Alison, Merrill, Deanna, Urbaityte, Rimgaile, Li, Bo, Andrae, David, Bonner, Courtney, Herbst, Abigail, Chowdhury, Dhuly, Garges, Harmony, Czarnogorski, Maggie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678178/
http://dx.doi.org/10.1093/ofid/ofad500.1382
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author Valenti, William M
Phoenix, John
Patel, Rupa R
Tims-Cook, Zandraetta
Pilgrim, Nanlesta
Haley, Amber
Sutton, Kenneth
Gaudion, Alison
Merrill, Deanna
Urbaityte, Rimgaile
Li, Bo
Andrae, David
Bonner, Courtney
Herbst, Abigail
Chowdhury, Dhuly
Garges, Harmony
Czarnogorski, Maggie
author_facet Valenti, William M
Phoenix, John
Patel, Rupa R
Tims-Cook, Zandraetta
Pilgrim, Nanlesta
Haley, Amber
Sutton, Kenneth
Gaudion, Alison
Merrill, Deanna
Urbaityte, Rimgaile
Li, Bo
Andrae, David
Bonner, Courtney
Herbst, Abigail
Chowdhury, Dhuly
Garges, Harmony
Czarnogorski, Maggie
author_sort Valenti, William M
collection PubMed
description BACKGROUND: EBONI and PILLAR are Phase IV implementation science trials evaluating the integration of long-acting injectable Cabotegravir for PrEP (CAB LA) into standard of care at 37 clinics across the U.S. EBONI enrolls Black cisgender/transgender women and PILLAR enrolls men who have sex with men (MSM)/transgender men. We report CAB LA implementation plans among staff study participants (SSPs). METHODS: Of 105 SSPs from 20 EBONI sites, 65 (62%) from 14 activated clinics completed baseline surveys starting in August 2022. Eighty-six (100%) SSPs from all 17 PILLAR clinic sites completed surveys from April-October 2022. Various clinic types were selected to enroll diverse populations. Survey domains included SSPs’ perceptions of implementing CAB LA, plans for integration, and estimation of resources needed for integration were collected. RESULTS: Table 1 presents notable gender and racial differences among SSPs across the studies. Table 2 reveals similar SSPs’ experience with PrEP and injections within the two studies. A high proportion of SSPs (EBONI: 97%; PILLAR: 85%) felt extremely positive or positive about implementing CAB LA. The majority of SSPs in EBONI (74%) than in PILLAR (53%) perceived implementation would be very easy or easy. Regarding CAB LA integration plans, compared to EBONI, SSPs in PILLAR reported being able to manage more CAB LA patients per week; having more staff prepared to give injections; having a specific person to follow up with no-shows; planning to have providers track patients; and planning to offer drop-in injection options (Table 3). However, more SSPs in EBONI reported plans to create roles to coordinate the CAB LA program. Various appointment reminder tools are in place and used in similarly high proportions across both studies. However, a higher proportion of SSPs in PILLAR reported using email and postal reminders. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: Healthcare staff were positive about integrating CAB LA into care. Sites serving MSM and transgender men had more detailed implementation plans in place than those serving cisgender and transgender women. Sites serving women may need additional support to develop their plans to build staff and clinic capacity. To address the gaps identified in clinic planning, an equity-centered implementation strategy should be employed. DISCLOSURES: William M. Valenti, MD, FIDSA, Gilead: Grant/Research Support|ViiV Healthcare: Grant/Research Support John Phoenix, MSN, APRN, FNP-C, Gilead: Grant/Research Support|Gilead: Speaker Bureau|Huntridge Family Clinic: Ownership Interest|Napo Pharmaceuticals: Speaker Bureau|ViiV Healthcare: Grant/Research Support|ViiV Healthcare: Speaker Bureau Rupa R. Patel, MD MPH, Gilead: Advisor/Consultant|Gilead: Grant/Research Support|Roche: Advisor/Consultant|ViiV Healthcare: Advisor/Consultant|ViiV Healthcare: Grant/Research Support Zandraetta Tims-Cook, MD, ViiV Healthcare: Speaker Nanlesta Pilgrim, PhD, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Amber Haley, PhD, ViiV Healthcare: Former Employment Kenneth Sutton, MA, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Alison Gaudion, PhD, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Deanna Merrill, PharmD, MBA, AAHIVP, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Rimgaile Urbaityte, MSc, GSK: Employment|GSK: Stocks/Bonds Bo Li, PhD, GSK: Employment|GSK: Stocks/Bonds David Andrae, PhD, Evidera: Employment Abigail Herbst, MPH, Evidera: Empoyment|ViiV Healthcare: Grant/Research Support Harmony Garges, MD, GSK: Stocks/Bonds|Medexus Pharmacy: Board Member|ViiV Healthcare: Empoyment Maggie Czarnogorski, MD MPH, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds
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spelling pubmed-106781782023-11-27 1547. Integrating Long-acting Injectable Cabotegravir for PrEP into Standard of Care for Cisgender Women, Transgender Women, Transgender Men, and Men Who Have Sex with Men: Results from the PILLAR & EBONI Studies Valenti, William M Phoenix, John Patel, Rupa R Tims-Cook, Zandraetta Pilgrim, Nanlesta Haley, Amber Sutton, Kenneth Gaudion, Alison Merrill, Deanna Urbaityte, Rimgaile Li, Bo Andrae, David Bonner, Courtney Herbst, Abigail Chowdhury, Dhuly Garges, Harmony Czarnogorski, Maggie Open Forum Infect Dis Abstract BACKGROUND: EBONI and PILLAR are Phase IV implementation science trials evaluating the integration of long-acting injectable Cabotegravir for PrEP (CAB LA) into standard of care at 37 clinics across the U.S. EBONI enrolls Black cisgender/transgender women and PILLAR enrolls men who have sex with men (MSM)/transgender men. We report CAB LA implementation plans among staff study participants (SSPs). METHODS: Of 105 SSPs from 20 EBONI sites, 65 (62%) from 14 activated clinics completed baseline surveys starting in August 2022. Eighty-six (100%) SSPs from all 17 PILLAR clinic sites completed surveys from April-October 2022. Various clinic types were selected to enroll diverse populations. Survey domains included SSPs’ perceptions of implementing CAB LA, plans for integration, and estimation of resources needed for integration were collected. RESULTS: Table 1 presents notable gender and racial differences among SSPs across the studies. Table 2 reveals similar SSPs’ experience with PrEP and injections within the two studies. A high proportion of SSPs (EBONI: 97%; PILLAR: 85%) felt extremely positive or positive about implementing CAB LA. The majority of SSPs in EBONI (74%) than in PILLAR (53%) perceived implementation would be very easy or easy. Regarding CAB LA integration plans, compared to EBONI, SSPs in PILLAR reported being able to manage more CAB LA patients per week; having more staff prepared to give injections; having a specific person to follow up with no-shows; planning to have providers track patients; and planning to offer drop-in injection options (Table 3). However, more SSPs in EBONI reported plans to create roles to coordinate the CAB LA program. Various appointment reminder tools are in place and used in similarly high proportions across both studies. However, a higher proportion of SSPs in PILLAR reported using email and postal reminders. [Figure: see text] [Figure: see text] [Figure: see text] CONCLUSION: Healthcare staff were positive about integrating CAB LA into care. Sites serving MSM and transgender men had more detailed implementation plans in place than those serving cisgender and transgender women. Sites serving women may need additional support to develop their plans to build staff and clinic capacity. To address the gaps identified in clinic planning, an equity-centered implementation strategy should be employed. DISCLOSURES: William M. Valenti, MD, FIDSA, Gilead: Grant/Research Support|ViiV Healthcare: Grant/Research Support John Phoenix, MSN, APRN, FNP-C, Gilead: Grant/Research Support|Gilead: Speaker Bureau|Huntridge Family Clinic: Ownership Interest|Napo Pharmaceuticals: Speaker Bureau|ViiV Healthcare: Grant/Research Support|ViiV Healthcare: Speaker Bureau Rupa R. Patel, MD MPH, Gilead: Advisor/Consultant|Gilead: Grant/Research Support|Roche: Advisor/Consultant|ViiV Healthcare: Advisor/Consultant|ViiV Healthcare: Grant/Research Support Zandraetta Tims-Cook, MD, ViiV Healthcare: Speaker Nanlesta Pilgrim, PhD, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Amber Haley, PhD, ViiV Healthcare: Former Employment Kenneth Sutton, MA, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Alison Gaudion, PhD, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Deanna Merrill, PharmD, MBA, AAHIVP, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Rimgaile Urbaityte, MSc, GSK: Employment|GSK: Stocks/Bonds Bo Li, PhD, GSK: Employment|GSK: Stocks/Bonds David Andrae, PhD, Evidera: Employment Abigail Herbst, MPH, Evidera: Empoyment|ViiV Healthcare: Grant/Research Support Harmony Garges, MD, GSK: Stocks/Bonds|Medexus Pharmacy: Board Member|ViiV Healthcare: Empoyment Maggie Czarnogorski, MD MPH, ViiV Healthcare: Employment|ViiV Healthcare: Stocks/Bonds Oxford University Press 2023-11-27 /pmc/articles/PMC10678178/ http://dx.doi.org/10.1093/ofid/ofad500.1382 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Valenti, William M
Phoenix, John
Patel, Rupa R
Tims-Cook, Zandraetta
Pilgrim, Nanlesta
Haley, Amber
Sutton, Kenneth
Gaudion, Alison
Merrill, Deanna
Urbaityte, Rimgaile
Li, Bo
Andrae, David
Bonner, Courtney
Herbst, Abigail
Chowdhury, Dhuly
Garges, Harmony
Czarnogorski, Maggie
1547. Integrating Long-acting Injectable Cabotegravir for PrEP into Standard of Care for Cisgender Women, Transgender Women, Transgender Men, and Men Who Have Sex with Men: Results from the PILLAR & EBONI Studies
title 1547. Integrating Long-acting Injectable Cabotegravir for PrEP into Standard of Care for Cisgender Women, Transgender Women, Transgender Men, and Men Who Have Sex with Men: Results from the PILLAR & EBONI Studies
title_full 1547. Integrating Long-acting Injectable Cabotegravir for PrEP into Standard of Care for Cisgender Women, Transgender Women, Transgender Men, and Men Who Have Sex with Men: Results from the PILLAR & EBONI Studies
title_fullStr 1547. Integrating Long-acting Injectable Cabotegravir for PrEP into Standard of Care for Cisgender Women, Transgender Women, Transgender Men, and Men Who Have Sex with Men: Results from the PILLAR & EBONI Studies
title_full_unstemmed 1547. Integrating Long-acting Injectable Cabotegravir for PrEP into Standard of Care for Cisgender Women, Transgender Women, Transgender Men, and Men Who Have Sex with Men: Results from the PILLAR & EBONI Studies
title_short 1547. Integrating Long-acting Injectable Cabotegravir for PrEP into Standard of Care for Cisgender Women, Transgender Women, Transgender Men, and Men Who Have Sex with Men: Results from the PILLAR & EBONI Studies
title_sort 1547. integrating long-acting injectable cabotegravir for prep into standard of care for cisgender women, transgender women, transgender men, and men who have sex with men: results from the pillar & eboni studies
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678178/
http://dx.doi.org/10.1093/ofid/ofad500.1382
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