Cargando…

1610. Adherence to Antiretroviral Therapy and Its Effect on Quality of Life among Persons with HIV in the United States using Real-World Data

BACKGROUND: Adherence to antiretroviral therapy (ART) is critical for persons with HIV (PWH) for achieving durable virologic suppression and minimizing drug resistance. This study aimed to characterize ART adherence and its effect on quality of life (QoL) among PWH using real-world data. METHODS: Da...

Descripción completa

Detalles Bibliográficos
Autores principales: Hennessy, Fritha, Prajapati, Girish, Salmon, Phoebe, Holbrook, Tim, Tadese, Bekana K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678216/
http://dx.doi.org/10.1093/ofid/ofad500.1445
_version_ 1785150309978341376
author Hennessy, Fritha
Prajapati, Girish
Salmon, Phoebe
Holbrook, Tim
Tadese, Bekana K
author_facet Hennessy, Fritha
Prajapati, Girish
Salmon, Phoebe
Holbrook, Tim
Tadese, Bekana K
author_sort Hennessy, Fritha
collection PubMed
description BACKGROUND: Adherence to antiretroviral therapy (ART) is critical for persons with HIV (PWH) for achieving durable virologic suppression and minimizing drug resistance. This study aimed to characterize ART adherence and its effect on quality of life (QoL) among PWH using real-world data. METHODS: Data were drawn from the Adelphi HIV Disease Specific Programme™, a cross-sectional survey of physicians and PWH in the U.S., collected between July-2021 and March-2022. At consultation, each of 60 physicians reported demographics, clinical characteristics, ART adherence and satisfaction on 10 consenting PWH. These PWH were then invited to complete questionnaires reporting QoL (PozQol, EQ-5D). Physicians categorized adherence as completely adherent (C-Adh), mostly adherent (M-Adh), or less adherent (L-Adh). Comparisons were made using Chi squared test. RESULTS: Of 578 PWH with physician-reported adherence status; mean [SD] age 44.9 [12.8] years, 70.4% cisgender male, 50.5% White. A total of 389 (67%) were C-Adh, 155 (27%) M-Adh, and 34 (6%) L-Adh. L-Adh (55.9%) and M-Adh (46.5%) PWH had the higher proportion of ART side effects compared to C-Adh (29.3%); p< 0.001. Also, L-Adh (75.8%) and M-Adh (50.8%) were more likely to report current HIV-associated symptoms than C-Adh PWH (29.3%); p< 0.001. C-Adh PWH were perceived as very satisfied with their ART (68.4%), compared to M-Adh 39.4% and L-Adh 23.5%; p< 0.001. Reasons for PWH skipping ART included forgetting, difficulties integrating into routine, and ART side effects (Figure 1). QOL survey was completed by 229 PWH. QoL was higher for C-Adh PWH, measured by PozQol score mean, (C-Adh;45.2, M-Adh ;40.7, L-Adh;42.0; p< 0.05) and EQ-5D score mean (C-Adh; 0.91, M-Adh;0.77, L-Adh;0.66; p< 0.001). [Figure: see text] CONCLUSION: About one-third of PWH who were not fully adherent to ART, and this was correlated with having poorer QoL. These findings highlight the need to better understand factors leading to sub-optimal ART adherence, to provide targeted interventions to improve quality of life. DISCLOSURES: Girish Prajapati, M.B.B.S., MPH , Merck & Co., Inc.: Employee|Merck & Co., Inc.: Stocks/Bonds Bekana K. Tadese, PhD, MPH, Merck and Co Inc: Employee
format Online
Article
Text
id pubmed-10678216
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Oxford University Press
record_format MEDLINE/PubMed
spelling pubmed-106782162023-11-27 1610. Adherence to Antiretroviral Therapy and Its Effect on Quality of Life among Persons with HIV in the United States using Real-World Data Hennessy, Fritha Prajapati, Girish Salmon, Phoebe Holbrook, Tim Tadese, Bekana K Open Forum Infect Dis Abstract BACKGROUND: Adherence to antiretroviral therapy (ART) is critical for persons with HIV (PWH) for achieving durable virologic suppression and minimizing drug resistance. This study aimed to characterize ART adherence and its effect on quality of life (QoL) among PWH using real-world data. METHODS: Data were drawn from the Adelphi HIV Disease Specific Programme™, a cross-sectional survey of physicians and PWH in the U.S., collected between July-2021 and March-2022. At consultation, each of 60 physicians reported demographics, clinical characteristics, ART adherence and satisfaction on 10 consenting PWH. These PWH were then invited to complete questionnaires reporting QoL (PozQol, EQ-5D). Physicians categorized adherence as completely adherent (C-Adh), mostly adherent (M-Adh), or less adherent (L-Adh). Comparisons were made using Chi squared test. RESULTS: Of 578 PWH with physician-reported adherence status; mean [SD] age 44.9 [12.8] years, 70.4% cisgender male, 50.5% White. A total of 389 (67%) were C-Adh, 155 (27%) M-Adh, and 34 (6%) L-Adh. L-Adh (55.9%) and M-Adh (46.5%) PWH had the higher proportion of ART side effects compared to C-Adh (29.3%); p< 0.001. Also, L-Adh (75.8%) and M-Adh (50.8%) were more likely to report current HIV-associated symptoms than C-Adh PWH (29.3%); p< 0.001. C-Adh PWH were perceived as very satisfied with their ART (68.4%), compared to M-Adh 39.4% and L-Adh 23.5%; p< 0.001. Reasons for PWH skipping ART included forgetting, difficulties integrating into routine, and ART side effects (Figure 1). QOL survey was completed by 229 PWH. QoL was higher for C-Adh PWH, measured by PozQol score mean, (C-Adh;45.2, M-Adh ;40.7, L-Adh;42.0; p< 0.05) and EQ-5D score mean (C-Adh; 0.91, M-Adh;0.77, L-Adh;0.66; p< 0.001). [Figure: see text] CONCLUSION: About one-third of PWH who were not fully adherent to ART, and this was correlated with having poorer QoL. These findings highlight the need to better understand factors leading to sub-optimal ART adherence, to provide targeted interventions to improve quality of life. DISCLOSURES: Girish Prajapati, M.B.B.S., MPH , Merck & Co., Inc.: Employee|Merck & Co., Inc.: Stocks/Bonds Bekana K. Tadese, PhD, MPH, Merck and Co Inc: Employee Oxford University Press 2023-11-27 /pmc/articles/PMC10678216/ http://dx.doi.org/10.1093/ofid/ofad500.1445 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
Hennessy, Fritha
Prajapati, Girish
Salmon, Phoebe
Holbrook, Tim
Tadese, Bekana K
1610. Adherence to Antiretroviral Therapy and Its Effect on Quality of Life among Persons with HIV in the United States using Real-World Data
title 1610. Adherence to Antiretroviral Therapy and Its Effect on Quality of Life among Persons with HIV in the United States using Real-World Data
title_full 1610. Adherence to Antiretroviral Therapy and Its Effect on Quality of Life among Persons with HIV in the United States using Real-World Data
title_fullStr 1610. Adherence to Antiretroviral Therapy and Its Effect on Quality of Life among Persons with HIV in the United States using Real-World Data
title_full_unstemmed 1610. Adherence to Antiretroviral Therapy and Its Effect on Quality of Life among Persons with HIV in the United States using Real-World Data
title_short 1610. Adherence to Antiretroviral Therapy and Its Effect on Quality of Life among Persons with HIV in the United States using Real-World Data
title_sort 1610. adherence to antiretroviral therapy and its effect on quality of life among persons with hiv in the united states using real-world data
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678216/
http://dx.doi.org/10.1093/ofid/ofad500.1445
work_keys_str_mv AT hennessyfritha 1610adherencetoantiretroviraltherapyanditseffectonqualityoflifeamongpersonswithhivintheunitedstatesusingrealworlddata
AT prajapatigirish 1610adherencetoantiretroviraltherapyanditseffectonqualityoflifeamongpersonswithhivintheunitedstatesusingrealworlddata
AT salmonphoebe 1610adherencetoantiretroviraltherapyanditseffectonqualityoflifeamongpersonswithhivintheunitedstatesusingrealworlddata
AT holbrooktim 1610adherencetoantiretroviraltherapyanditseffectonqualityoflifeamongpersonswithhivintheunitedstatesusingrealworlddata
AT tadesebekanak 1610adherencetoantiretroviraltherapyanditseffectonqualityoflifeamongpersonswithhivintheunitedstatesusingrealworlddata