2395. An Interim Report of the Safety, Reactogenicity, and Immunogenicity of a Self-amplifying mRNA (samRNA) COVID-19 Vaccine GRT-R910 as a Booster in Healthy Adults

BACKGROUND: GRT-R910 (Gritstone bio, Inc), a self-amplifying mRNA (samRNA) vaccine expressing the spike protein plus T-cell epitopes of SARS-CoV-2 (D614G variant), was tested in a phase 1 study as a booster in healthy adults. METHODS: This phase 1 open-label, dose escalation study enrolled healthy a...

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Detalles Bibliográficos
Autores principales: Whitaker, Jennifer, Rebolledo, Paulina, Rouphael, Nadine, Abate, Getahun, Babu, Tara M, Wald, Anna, Sahly, Hana El, Garbes, Pedro, Jooss, Karin, Allen, Andrew, McQuarrie, Lisa, Sitaula, Ranjan, Roberts, Paul C, Makhene, Mamodikoe, Posavad, Christine M, Juliana McElrath, M, De Rosa, Stephen, Coler, Rhea, Montefiori, David, Eaton, Amanda, Koelle, David M, Hoft, Daniel F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678310/
http://dx.doi.org/10.1093/ofid/ofad500.2015

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