304. Immunoproteasome Inhibition Augments Endoplasmic Reticulum Stress and Enhances Disease During Coronavirus Respiratory Infection

BACKGROUND: Inflammation contributes to disease in patients with SARS-CoV-2 infection. The immunoproteasome (IP), an inducible component of the ubiquitin-proteasome system, contributes to the diversity of T cell epitopes generated during infection and production of antiviral and pro-inflammatory cyt...

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Detalles Bibliográficos
Autores principales: Steigmann, Jacob C, Suttenberg, Lauren, Zhou, Xiaofeng, Weinberg, Jason
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678473/
http://dx.doi.org/10.1093/ofid/ofad500.376

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