2183. Porin Mutations Potentiate the in Vitro Synergy of Meropenem-Vaborbactam (MVB), but not Ceftazidime-Avibactam (CZA) in Combination with Other Antibiotics against KPC-producing Klebsiella Pneumoniae (KPC-Kp)

BACKGROUND: CZA and MVB are often used in combination with other antibiotics in clinical practice. Our objective was to assess their in vitro synergy stratified by predominant ompK36 genotype: wild-type (WT), or mutants that included an insertion sequence 5 (IS5) or GD duplication (GD). METHODS: 15...

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Detalles Bibliográficos
Autores principales: Rogers, Tara M, Kline, Ellen G, Squires, Kevin M, Jones, Chelsea, Shields, Ryan K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678505/
http://dx.doi.org/10.1093/ofid/ofad500.1805

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678505/
http://dx.doi.org/10.1093/ofid/ofad500.1805

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