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2637. Activity of Respiratory Viruses in Georgia 2020-2022

BACKGROUND: The emergence of SARS-CoV-2 in early 2020 with subsequent implementation of public health and social measures influenced the epidemiology of respiratory viruses worldwide. This study describes circulation of respiratory viruses during two winter seasons and inter-seasonal periods in Geor...

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Autores principales: machablishvili, Ann, Tarkhan-Mouravi, Olgha, Zakhashvili, Khatuna, Kalandadze, Irina, Karseladze, Irakli, Gavashelidze, Mari, Imnadze, Paata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678577/
http://dx.doi.org/10.1093/ofid/ofad500.2249
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author machablishvili, Ann
Tarkhan-Mouravi, Olgha
Zakhashvili, Khatuna
Kalandadze, Irina
Karseladze, Irakli
Gavashelidze, Mari
Imnadze, Paata
author_facet machablishvili, Ann
Tarkhan-Mouravi, Olgha
Zakhashvili, Khatuna
Kalandadze, Irina
Karseladze, Irakli
Gavashelidze, Mari
Imnadze, Paata
author_sort machablishvili, Ann
collection PubMed
description BACKGROUND: The emergence of SARS-CoV-2 in early 2020 with subsequent implementation of public health and social measures influenced the epidemiology of respiratory viruses worldwide. This study describes circulation of respiratory viruses during two winter seasons and inter-seasonal periods in Georgia. METHODS: We aggregated data obtained from Influenza like illness (ILI) and Severe Acute Respiratory Infection (SARI) cases during 2020/21 and 2021/22 (weeks 40-20) and inter-seasonal (weeks 21-39) periods in Georgia. All specimens from patients were screened on 22 respiratory viruses by real time RT-PCR. RESULTS: During 2020/21 season 50% (868/1729) specimens tested positive on at least one virus. No influenza virus and few RSV detections were observed in Georgia. Mostly identified virus was Rhino (44.8%) circulating almost all season; followed by Coronavirus OC43 (23.7%), primarily seen in weeks 12-18 and SARS-Cov-2 (15%) with highest detection rates during weeks 48-52. In 2021 inter-season 54% (825/1513) of specimens were positive. A gradual increase in RSV detections was observed in summer. Most seen viruses were Rhino (30%), HMPV (22%) and Parainfluenza virus 3 (21%) circulating mainly in June and July. During 2021/22 season 44% (2012/4545) of specimens screened positive, out of which RSV (25.7%) with earlier circulation in weeks 40-2 and Rhino (25.7%) with most detections in the beginning and at the end of the season. Unusually influenza A/H3 (17%) peaked in late spring (weeks 12-18). SARS-Cov-2, Parainfluenza viruses 3 and 4, Adenoviruses, Human bocavirus, enteroviruses were actively co-circulating too. In 2022 inter-season 54% (1320/2456) of samples tested positive. Influenza A/H3 circulation continued until July. SARS-Cov-2 (27.7%), Rhino (22%), HMPV (14.5%), Parainfluenza virus 3 (12.7%), RSV (10.8%) were mostly seen viruses predominantly in June. CONCLUSION: Wider range respiratory viruses with higher positivity rates were detected among ILI and SARI cases in 2021/22 season compared to 2020/21 presumably due to mitigation of public health and social measures. Low detection rates of SARS-CoV-2 at sentinel sites could be explained by referral of COVID-19 patients to dedicated clinics. RSV and Influenza circulations were unusual in summer months in Georgia. DISCLOSURES: All Authors: No reported disclosures
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spelling pubmed-106785772023-11-27 2637. Activity of Respiratory Viruses in Georgia 2020-2022 machablishvili, Ann Tarkhan-Mouravi, Olgha Zakhashvili, Khatuna Kalandadze, Irina Karseladze, Irakli Gavashelidze, Mari Imnadze, Paata Open Forum Infect Dis Abstract BACKGROUND: The emergence of SARS-CoV-2 in early 2020 with subsequent implementation of public health and social measures influenced the epidemiology of respiratory viruses worldwide. This study describes circulation of respiratory viruses during two winter seasons and inter-seasonal periods in Georgia. METHODS: We aggregated data obtained from Influenza like illness (ILI) and Severe Acute Respiratory Infection (SARI) cases during 2020/21 and 2021/22 (weeks 40-20) and inter-seasonal (weeks 21-39) periods in Georgia. All specimens from patients were screened on 22 respiratory viruses by real time RT-PCR. RESULTS: During 2020/21 season 50% (868/1729) specimens tested positive on at least one virus. No influenza virus and few RSV detections were observed in Georgia. Mostly identified virus was Rhino (44.8%) circulating almost all season; followed by Coronavirus OC43 (23.7%), primarily seen in weeks 12-18 and SARS-Cov-2 (15%) with highest detection rates during weeks 48-52. In 2021 inter-season 54% (825/1513) of specimens were positive. A gradual increase in RSV detections was observed in summer. Most seen viruses were Rhino (30%), HMPV (22%) and Parainfluenza virus 3 (21%) circulating mainly in June and July. During 2021/22 season 44% (2012/4545) of specimens screened positive, out of which RSV (25.7%) with earlier circulation in weeks 40-2 and Rhino (25.7%) with most detections in the beginning and at the end of the season. Unusually influenza A/H3 (17%) peaked in late spring (weeks 12-18). SARS-Cov-2, Parainfluenza viruses 3 and 4, Adenoviruses, Human bocavirus, enteroviruses were actively co-circulating too. In 2022 inter-season 54% (1320/2456) of samples tested positive. Influenza A/H3 circulation continued until July. SARS-Cov-2 (27.7%), Rhino (22%), HMPV (14.5%), Parainfluenza virus 3 (12.7%), RSV (10.8%) were mostly seen viruses predominantly in June. CONCLUSION: Wider range respiratory viruses with higher positivity rates were detected among ILI and SARI cases in 2021/22 season compared to 2020/21 presumably due to mitigation of public health and social measures. Low detection rates of SARS-CoV-2 at sentinel sites could be explained by referral of COVID-19 patients to dedicated clinics. RSV and Influenza circulations were unusual in summer months in Georgia. DISCLOSURES: All Authors: No reported disclosures Oxford University Press 2023-11-27 /pmc/articles/PMC10678577/ http://dx.doi.org/10.1093/ofid/ofad500.2249 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
machablishvili, Ann
Tarkhan-Mouravi, Olgha
Zakhashvili, Khatuna
Kalandadze, Irina
Karseladze, Irakli
Gavashelidze, Mari
Imnadze, Paata
2637. Activity of Respiratory Viruses in Georgia 2020-2022
title 2637. Activity of Respiratory Viruses in Georgia 2020-2022
title_full 2637. Activity of Respiratory Viruses in Georgia 2020-2022
title_fullStr 2637. Activity of Respiratory Viruses in Georgia 2020-2022
title_full_unstemmed 2637. Activity of Respiratory Viruses in Georgia 2020-2022
title_short 2637. Activity of Respiratory Viruses in Georgia 2020-2022
title_sort 2637. activity of respiratory viruses in georgia 2020-2022
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678577/
http://dx.doi.org/10.1093/ofid/ofad500.2249
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