2957. Decreased microbial diversity and baseline intestinal inflammation are associated with worse outcome in aged, female mice infected with Clostridioides difficile

BACKGROUND: C. difficile infection is more common and severe in people over 65-years old. Understanding the pathogenesis within the triangle of host, pathogen, and the microbiota in aged population will help decrease the disease severity. METHODS: Young (3-month-old) and aged (22 to 25-month-old) ma...

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Autores principales: Nguyen, Nhu, Vendrov, Kimberly, Abernathy-Close, Lisa, Dieterle, Michael, Young, Vincent B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678590/
http://dx.doi.org/10.1093/ofid/ofad500.196

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