375. The Effect of Inhaled Interferon Beta-1a (SNG001) Treatment Compared to Placebo on Lung Antiviral Biomarkers and Viral Clearance in Chronic Obstructive Pulmonary Disease (COPD) Patients With Respiratory Virus Infections

BACKGROUND: Respiratory viral infections (RVIs) are major drivers of chronic obstructive pulmonary disease (COPD) exacerbations. Interferon beta (IFN-β) is key in host defence against viruses but can be suppressed by virus or host factors locally at the site of infection. Inhalation of SNG001 (IFN-β...

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Detalles Bibliográficos
Autores principales: Monk, Phillip D, Brookes, Jody L, Tear, Victoria J, Batten, Toby, Newall, Clare, Mankowski, Marcin, Crooks, Michael G, Singh, Dave, Chaudhuri, Rekha, Lunn, Kerry, Reynolds, Sophie, Dudley, Sarah, Gabbay, Felicity, Holgate, Stephen T, Djukanovic, Ratko, Wilkinson, Tom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678701/
http://dx.doi.org/10.1093/ofid/ofad500.445

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