2792. Determining the activity of imipenem/relebactam (I/R) plus aztreonam (ATM) against constitutive Pseudomonas derived cephalosporinase (PDC)- and metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa in a hollow fiber infection model (HFIM)

BACKGROUND: Few treatment options exist for serious infections caused by MBL-PSA. While ATM retains activity against some MBL-PSA, isolates often constitutively produce PDCs, resulting in resistance. I/R is a new β-lactam/β-lactamase inhibitor with expanded activity against constitutive PDC-producin...

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Detalles Bibliográficos
Autores principales: O’Donnell, J Nicholas, Moolick, Kelly E, Nahorniak, Avery I, Gifford, Maxwell J, Young, Katherine, Lodise, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10678881/
http://dx.doi.org/10.1093/ofid/ofad500.2403

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