2343. SARS-CoV-2 Spike Conformation Essentially Influences Vaccine Immunogenicity – Results from Two Clinical Phase I Trials of the Vector Vaccine Candidates MVA-SARS-2-S and MVA-SARS-2-ST

BACKGROUND: Recombinant Modified Vaccinia virus Ankara (MVA) is a replication-deficient viral vector platform with a favorable safety profile that is currently developed for multiple indications, including vaccines against emerging infections. We assessed the safety and immunogenicity of two MVA-bas...

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Detalles Bibliográficos
Autores principales: Fathi, Anahita, Dahlke, Christine, Hardtke, Svenja, Mellinghoff, Sibylle C, Mayer, Leonie, Weskamm, Leonie M, Krähling, Verena, Müller-Kräuter, Helena, Ly, My L, Friedrich, Monika, Hesterkamp, Thomas J, Volz, Asisa, Sutter, Gerd, Becker, Stephan, Addo, Marylyn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Abstract
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679251/
http://dx.doi.org/10.1093/ofid/ofad500.1965

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