Age-induced nitrative stress decreases retrograde transport of proNGF via TrkA and increases proNGF retrograde transport and neurodegeneration via p75(NTR)

INTRODUCTION: Axonal transport of pro nerve growth factor (proNGF) is impaired in aged basal forebrain cholinergic neurons (BFCNs), which is associated with their degeneration. ProNGF is neurotrophic in the presence of its receptor tropomyosin-related kinase A (TrkA) but induces apoptosis via the pa...

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Detalles Bibliográficos
Autores principales: Kropf, Erika, Shekari, Arman, Jaberi, Sama, Puri, Anish, Wu, Chengbiao, Fahnestock, Margaret
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679388/
https://www.ncbi.nlm.nih.gov/pubmed/38025269
http://dx.doi.org/10.3389/fnmol.2023.1241420

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