Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report

Multiple morphological changes in two or more sites of concurrent multifocal mucinous lesions in the female genital tract are indicative of SMMN-FGT, which is unrelated to high-risk HPV infection. MUC6 and HIK-1083 showed positive characteristic immunohistochemistry. Seldom is the condition describe...

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Autores principales: Wang, Ru, Yu, Hao, Liu, Ming, Hao, Ting, Wang, Xiangyu, Cao, Lianbao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679390/
https://www.ncbi.nlm.nih.gov/pubmed/38023125
http://dx.doi.org/10.3389/fonc.2023.1246821
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author Wang, Ru
Yu, Hao
Liu, Ming
Hao, Ting
Wang, Xiangyu
Cao, Lianbao
author_facet Wang, Ru
Yu, Hao
Liu, Ming
Hao, Ting
Wang, Xiangyu
Cao, Lianbao
author_sort Wang, Ru
collection PubMed
description Multiple morphological changes in two or more sites of concurrent multifocal mucinous lesions in the female genital tract are indicative of SMMN-FGT, which is unrelated to high-risk HPV infection. MUC6 and HIK-1083 showed positive characteristic immunohistochemistry. Seldom is the condition described. Here we describe an SMMN-FGT patient who also had lung metastases and STK11/KRAS gene mutations. Based on the current researches, we hypothesize that SMMN-FGT is closely associated with the development of cervical gastric adenocarcinoma.
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spelling pubmed-106793902023-01-01 Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report Wang, Ru Yu, Hao Liu, Ming Hao, Ting Wang, Xiangyu Cao, Lianbao Front Oncol Oncology Multiple morphological changes in two or more sites of concurrent multifocal mucinous lesions in the female genital tract are indicative of SMMN-FGT, which is unrelated to high-risk HPV infection. MUC6 and HIK-1083 showed positive characteristic immunohistochemistry. Seldom is the condition described. Here we describe an SMMN-FGT patient who also had lung metastases and STK11/KRAS gene mutations. Based on the current researches, we hypothesize that SMMN-FGT is closely associated with the development of cervical gastric adenocarcinoma. Frontiers Media S.A. 2023-11-13 /pmc/articles/PMC10679390/ /pubmed/38023125 http://dx.doi.org/10.3389/fonc.2023.1246821 Text en Copyright © 2023 Wang, Yu, Liu, Hao, Wang and Cao https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Wang, Ru
Yu, Hao
Liu, Ming
Hao, Ting
Wang, Xiangyu
Cao, Lianbao
Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report
title Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report
title_full Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report
title_fullStr Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report
title_full_unstemmed Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report
title_short Synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and STK11/KRAS gene mutations: a case report
title_sort synchronous mucinous metaplasia and neoplasia of the female genital tract with both pulmonary metastases and stk11/kras gene mutations: a case report
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679390/
https://www.ncbi.nlm.nih.gov/pubmed/38023125
http://dx.doi.org/10.3389/fonc.2023.1246821
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