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More than just a gel: the extracellular matrixome of Pseudomonas aeruginosa

Armed with an arsenal of protein secretion systems, antibiotic efflux pumps, and the occasional proclivity for explosive self-destruction, Pseudomonas aeruginosa has become a model for the study of bacterial pathogenesis and biofilm formation. There is accruing evidence to suggest that the biofilm m...

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Detalles Bibliográficos
Autores principales: Nazeer, Rahan Rudland, Wang, Meng, Welch, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679415/
https://www.ncbi.nlm.nih.gov/pubmed/38028553
http://dx.doi.org/10.3389/fmolb.2023.1307857
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author Nazeer, Rahan Rudland
Wang, Meng
Welch, Martin
author_facet Nazeer, Rahan Rudland
Wang, Meng
Welch, Martin
author_sort Nazeer, Rahan Rudland
collection PubMed
description Armed with an arsenal of protein secretion systems, antibiotic efflux pumps, and the occasional proclivity for explosive self-destruction, Pseudomonas aeruginosa has become a model for the study of bacterial pathogenesis and biofilm formation. There is accruing evidence to suggest that the biofilm matrix—the bioglue that holds the structure together—acts not only in a structural capacity, but is also a molecular “net” whose function is to capture and retain certain secreted products (including proteins and small molecules). In this perspective, we argue that the biofilm matrixome is a distinct extracellular compartment, and one that is differentiated from the bulk secretome. Some of the points we raise are deliberately speculative, but are becoming increasingly accessible to experimental investigation.
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spelling pubmed-106794152023-01-01 More than just a gel: the extracellular matrixome of Pseudomonas aeruginosa Nazeer, Rahan Rudland Wang, Meng Welch, Martin Front Mol Biosci Molecular Biosciences Armed with an arsenal of protein secretion systems, antibiotic efflux pumps, and the occasional proclivity for explosive self-destruction, Pseudomonas aeruginosa has become a model for the study of bacterial pathogenesis and biofilm formation. There is accruing evidence to suggest that the biofilm matrix—the bioglue that holds the structure together—acts not only in a structural capacity, but is also a molecular “net” whose function is to capture and retain certain secreted products (including proteins and small molecules). In this perspective, we argue that the biofilm matrixome is a distinct extracellular compartment, and one that is differentiated from the bulk secretome. Some of the points we raise are deliberately speculative, but are becoming increasingly accessible to experimental investigation. Frontiers Media S.A. 2023-11-13 /pmc/articles/PMC10679415/ /pubmed/38028553 http://dx.doi.org/10.3389/fmolb.2023.1307857 Text en Copyright © 2023 Nazeer, Wang and Welch. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Nazeer, Rahan Rudland
Wang, Meng
Welch, Martin
More than just a gel: the extracellular matrixome of Pseudomonas aeruginosa
title More than just a gel: the extracellular matrixome of Pseudomonas aeruginosa
title_full More than just a gel: the extracellular matrixome of Pseudomonas aeruginosa
title_fullStr More than just a gel: the extracellular matrixome of Pseudomonas aeruginosa
title_full_unstemmed More than just a gel: the extracellular matrixome of Pseudomonas aeruginosa
title_short More than just a gel: the extracellular matrixome of Pseudomonas aeruginosa
title_sort more than just a gel: the extracellular matrixome of pseudomonas aeruginosa
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679415/
https://www.ncbi.nlm.nih.gov/pubmed/38028553
http://dx.doi.org/10.3389/fmolb.2023.1307857
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