E3 ubiquitin ligase ZBTB25 suppresses beta coronavirus infection through ubiquitination of the main viral protease MPro

The main protease of severe acute respiratory syndrome coronavirus 2, Mpro, is a key viral protein essential for viral infection and replication. Mpro has been the target of many pharmacological efforts; however, the host-specific regulation of Mpro protein remains unclear. Here, we report the ubiqu...

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Detalles Bibliográficos
Autores principales: Lear, Travis B., Boudreau, Áine N., Lockwood, Karina C., Chu, Elise, Camarco, Daniel P., Cao, Qing, Nguyen, Matthew, Evankovich, John W., Finkel, Toren, Liu, Yuan, Chen, Bill B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679490/
https://www.ncbi.nlm.nih.gov/pubmed/37890782
http://dx.doi.org/10.1016/j.jbc.2023.105388

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