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The toxicities of A30P and A53T α-synuclein fibrils can be uniquely altered by the length and saturation of fatty acids in phosphatidylserine

Progressive degeneration of dopaminergic neurons in the midbrain, hypothalamus, and thalamus is a hallmark of Parkinson’s disease (PD). Neuronal death is linked to the abrupt aggregation of α-synuclein (α-syn), a small protein that regulates vesicle trafficking in synaptic clefts. Studies of familie...

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Detalles Bibliográficos
Autores principales:	Ali, Abid, Zhaliazka, Kiryl, Dou, Tianyi, Holman, Aidan P., Kurouski, Dmitry
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679493/ https://www.ncbi.nlm.nih.gov/pubmed/37890776 http://dx.doi.org/10.1016/j.jbc.2023.105383

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