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Synthetic augmentation of bilirubin metabolism in human pluripotent stem cell-derived liver organoids

UGT1A1 (UDP glucuronosyltransferase family 1 member A1) is the primary enzyme required for bilirubin conjugation, which is essential for preventing hyperbilirubinemia. Animal models lack key human organic anion transporting polypeptides with distinct epigenetic control over bilirubin metabolism, nec...

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Detalles Bibliográficos
Autores principales:	Reza, Hasan Al, Farooqui, Zishaan, Reza, Abid Al, Conroy, Callen, Iwasawa, Kentaro, Ogura, Yasuhiro, Okita, Keisuke, Osafune, Kenji, Takebe, Takanori
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679658/ https://www.ncbi.nlm.nih.gov/pubmed/37832542 http://dx.doi.org/10.1016/j.stemcr.2023.09.006

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