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Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation

INTRODUCTION: Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used to study and treat several neurological conditions, but its complex molecular basis...

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Autores principales: Weiler, Marina, Stieger, Kevin C., Shroff, Kavisha, Klein, Jessie P., Wood, William H., Zhang, Yongqing, Chandrasekaran, Prabha, Lehrmann, Elin, Camandola, Simonetta, Long, Jeffrey M., Mattson, Mark P., Becker, Kevin G., Rapp, Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679736/
https://www.ncbi.nlm.nih.gov/pubmed/38021223
http://dx.doi.org/10.3389/fnhum.2023.1215291
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author Weiler, Marina
Stieger, Kevin C.
Shroff, Kavisha
Klein, Jessie P.
Wood, William H.
Zhang, Yongqing
Chandrasekaran, Prabha
Lehrmann, Elin
Camandola, Simonetta
Long, Jeffrey M.
Mattson, Mark P.
Becker, Kevin G.
Rapp, Peter R.
author_facet Weiler, Marina
Stieger, Kevin C.
Shroff, Kavisha
Klein, Jessie P.
Wood, William H.
Zhang, Yongqing
Chandrasekaran, Prabha
Lehrmann, Elin
Camandola, Simonetta
Long, Jeffrey M.
Mattson, Mark P.
Becker, Kevin G.
Rapp, Peter R.
author_sort Weiler, Marina
collection PubMed
description INTRODUCTION: Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used to study and treat several neurological conditions, but its complex molecular basis is largely unexplored. METHODS: Utilizing three experimental rat models (in vitro, ex vivo, and in vivo) and employing genome-wide microarray analysis, our study reveals the extensive impact of rTMS treatment on gene expression patterns. RESULTS: These effects are observed across various stimulation protocols, in diverse tissues, and are influenced by time and age. Notably, rTMS-induced alterations in gene expression span a wide range of biological pathways, such as glutamatergic, GABAergic, and anti-inflammatory pathways, ion channels, myelination, mitochondrial energetics, multiple neuron-and synapse-specific genes. DISCUSSION: This comprehensive transcriptional analysis induced by rTMS stimulation serves as a foundational characterization for subsequent experimental investigations and the exploration of potential clinical applications.
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spelling pubmed-106797362023-01-01 Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation Weiler, Marina Stieger, Kevin C. Shroff, Kavisha Klein, Jessie P. Wood, William H. Zhang, Yongqing Chandrasekaran, Prabha Lehrmann, Elin Camandola, Simonetta Long, Jeffrey M. Mattson, Mark P. Becker, Kevin G. Rapp, Peter R. Front Hum Neurosci Human Neuroscience INTRODUCTION: Transcranial Magnetic Stimulation (TMS) is a noninvasive technique that uses pulsed magnetic fields to affect the physiology of the brain and central nervous system. Repetitive TMS (rTMS) has been used to study and treat several neurological conditions, but its complex molecular basis is largely unexplored. METHODS: Utilizing three experimental rat models (in vitro, ex vivo, and in vivo) and employing genome-wide microarray analysis, our study reveals the extensive impact of rTMS treatment on gene expression patterns. RESULTS: These effects are observed across various stimulation protocols, in diverse tissues, and are influenced by time and age. Notably, rTMS-induced alterations in gene expression span a wide range of biological pathways, such as glutamatergic, GABAergic, and anti-inflammatory pathways, ion channels, myelination, mitochondrial energetics, multiple neuron-and synapse-specific genes. DISCUSSION: This comprehensive transcriptional analysis induced by rTMS stimulation serves as a foundational characterization for subsequent experimental investigations and the exploration of potential clinical applications. Frontiers Media S.A. 2023-11-13 /pmc/articles/PMC10679736/ /pubmed/38021223 http://dx.doi.org/10.3389/fnhum.2023.1215291 Text en Copyright © 2023 Weiler, Stieger, Shroff, Klein, Wood, Zhang, Chandrasekaran, Lehrmann, Camandola, Long, Mattson, Becker and Rapp. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Weiler, Marina
Stieger, Kevin C.
Shroff, Kavisha
Klein, Jessie P.
Wood, William H.
Zhang, Yongqing
Chandrasekaran, Prabha
Lehrmann, Elin
Camandola, Simonetta
Long, Jeffrey M.
Mattson, Mark P.
Becker, Kevin G.
Rapp, Peter R.
Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
title Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
title_full Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
title_fullStr Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
title_full_unstemmed Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
title_short Transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
title_sort transcriptional changes in the rat brain induced by repetitive transcranial magnetic stimulation
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679736/
https://www.ncbi.nlm.nih.gov/pubmed/38021223
http://dx.doi.org/10.3389/fnhum.2023.1215291
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