Neuronal models of TDP-43 proteinopathy display reduced axonal translation, increased oxidative stress, and defective exocytosis

Amyotrophic lateral sclerosis (ALS) is a progressive, lethal neurodegenerative disease mostly affecting people around 50–60 years of age. TDP-43, an RNA-binding protein involved in pre-mRNA splicing and controlling mRNA stability and translation, forms neuronal cytoplasmic inclusions in an overwhelm...

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Detalles Bibliográficos
Autores principales: Pisciottani, Alessandra, Croci, Laura, Lauria, Fabio, Marullo, Chiara, Savino, Elisa, Ambrosi, Alessandro, Podini, Paola, Marchioretto, Marta, Casoni, Filippo, Cremona, Ottavio, Taverna, Stefano, Quattrini, Angelo, Cioni, Jean-Michel, Viero, Gabriella, Codazzi, Franca, Consalez, G. Giacomo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679756/
https://www.ncbi.nlm.nih.gov/pubmed/38026702
http://dx.doi.org/10.3389/fncel.2023.1253543

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