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Hyperlipasemia Sans Pancreatitis: A Case Series
Acute pancreatitis results in inflammation and autodigestion of pancreatic acinar cells leading to the elevation of pancreatic enzymes, namely, amylase and lipase. Serum lipase levels have long been considered a hallmark of acute pancreatitis. However, pancreatitis is not always the cause of elevate...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679796/ https://www.ncbi.nlm.nih.gov/pubmed/38021537 http://dx.doi.org/10.7759/cureus.47781 |
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author | George, Jisa Gnanamoorthy, Kothai Suthakaran, Prasanna Karthik Baliga, Krishna Venkatesh |
author_facet | George, Jisa Gnanamoorthy, Kothai Suthakaran, Prasanna Karthik Baliga, Krishna Venkatesh |
author_sort | George, Jisa |
collection | PubMed |
description | Acute pancreatitis results in inflammation and autodigestion of pancreatic acinar cells leading to the elevation of pancreatic enzymes, namely, amylase and lipase. Serum lipase levels have long been considered a hallmark of acute pancreatitis. However, pancreatitis is not always the cause of elevated serum lipase levels. This series presents four patients who had elevated serum lipase levels without any demonstrable damage to the pancreas on imaging. On further evaluation, one of the patients was found to have acute on chronic kidney disease (CKD) whose lipase levels settled later. A patient presenting with an episode of acute gastroenteritis, later diagnosed to have Crohn’s disease, also had hyperlipasemia, which improved after a course of initial antibiotics. Non-gastrointestinal causes, such as lupus nephritis and organophosphate (OP) poisoning, also had elevated lipase levels on presentation, in which the hyperlipasemia settled with supportive treatments. It is important to remember other causes of elevated lipase levels in patients with a normal pancreas on imaging studies. |
format | Online Article Text |
id | pubmed-10679796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-106797962023-10-27 Hyperlipasemia Sans Pancreatitis: A Case Series George, Jisa Gnanamoorthy, Kothai Suthakaran, Prasanna Karthik Baliga, Krishna Venkatesh Cureus Internal Medicine Acute pancreatitis results in inflammation and autodigestion of pancreatic acinar cells leading to the elevation of pancreatic enzymes, namely, amylase and lipase. Serum lipase levels have long been considered a hallmark of acute pancreatitis. However, pancreatitis is not always the cause of elevated serum lipase levels. This series presents four patients who had elevated serum lipase levels without any demonstrable damage to the pancreas on imaging. On further evaluation, one of the patients was found to have acute on chronic kidney disease (CKD) whose lipase levels settled later. A patient presenting with an episode of acute gastroenteritis, later diagnosed to have Crohn’s disease, also had hyperlipasemia, which improved after a course of initial antibiotics. Non-gastrointestinal causes, such as lupus nephritis and organophosphate (OP) poisoning, also had elevated lipase levels on presentation, in which the hyperlipasemia settled with supportive treatments. It is important to remember other causes of elevated lipase levels in patients with a normal pancreas on imaging studies. Cureus 2023-10-27 /pmc/articles/PMC10679796/ /pubmed/38021537 http://dx.doi.org/10.7759/cureus.47781 Text en Copyright © 2023, George et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine George, Jisa Gnanamoorthy, Kothai Suthakaran, Prasanna Karthik Baliga, Krishna Venkatesh Hyperlipasemia Sans Pancreatitis: A Case Series |
title | Hyperlipasemia Sans Pancreatitis: A Case Series |
title_full | Hyperlipasemia Sans Pancreatitis: A Case Series |
title_fullStr | Hyperlipasemia Sans Pancreatitis: A Case Series |
title_full_unstemmed | Hyperlipasemia Sans Pancreatitis: A Case Series |
title_short | Hyperlipasemia Sans Pancreatitis: A Case Series |
title_sort | hyperlipasemia sans pancreatitis: a case series |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679796/ https://www.ncbi.nlm.nih.gov/pubmed/38021537 http://dx.doi.org/10.7759/cureus.47781 |
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