Neocortical neuronal production and maturation defects in the TcMAC21 mouse model of Down syndrome

Down syndrome (DS) results from trisomy of human chromosome 21 (HSA21), and DS research has been conducted by the use of mouse models. We previously generated a humanized mouse model of DS, TcMAC21, which carries the long arm of HSA21. These mice exhibit learning and memory deficits, and may reprodu...

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Detalles Bibliográficos
Autores principales: Kurabayashi, Nobuhiro, Fujii, Kazuki, Otobe, Yuta, Hiroki, Shingo, Hiratsuka, Masaharu, Yoshitane, Hikari, Kazuki, Yasuhiro, Takao, Keizo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679816/
https://www.ncbi.nlm.nih.gov/pubmed/38025769
http://dx.doi.org/10.1016/j.isci.2023.108379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679816/
https://www.ncbi.nlm.nih.gov/pubmed/38025769
http://dx.doi.org/10.1016/j.isci.2023.108379

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