ACE2-independent SARS-CoV-2 virus entry through cell surface GRP78 on monocytes – evidence from a translational clinical and experimental approach

BACKGROUND: SARS-CoV-2 infects host cells via an ACE2/TMPRSS2 entry mechanism. Monocytes and macrophages, which play a key role during severe COVID-19 express only low or no ACE2, suggesting alternative entry mechanisms in these cells. In silico analyses predicted GRP78, which is constitutively expr...

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Detalles Bibliográficos
Autores principales: Han, Bing, Lv, Yibing, Moser, Dominique, Zhou, Xiaoqi, Woehrle, Tobias, Han, Lianyong, Osterman, Andreas, Rudelius, Martina, Choukér, Alexander, Lei, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679867/
https://www.ncbi.nlm.nih.gov/pubmed/37967509
http://dx.doi.org/10.1016/j.ebiom.2023.104869

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