Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIV(mac239) in rhesus macaques

The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces cell-cycle arrest in cell culture. However, its impact in vivo is controversial. Here, we show that deletion of vpr is associated with delayed...

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Detalles Bibliográficos
Autores principales: Laliberté, Alexandre, Prelli Bozzo, Caterina, Stahl-Hennig, Christiane, Hunszinger, Victoria, Joas, Simone, Sauermann, Ulrike, Roshani, Berit, Klippert, Antonina, Daskalaki, Maria, Mätz-Rensing, Kerstin, Stolte-Leeb, Nicole, Tharp, Gregory K., Fuchs, Dietmar, Gupta, Prachi Mehrotra, Silvestri, Guido, Nelson, Sydney A., Parodi, Laura, Giavedoni, Luis, Bosinger, Steven E., Sparrer, Konstantin M.J., Kirchhoff, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10679897/
https://www.ncbi.nlm.nih.gov/pubmed/38025783
http://dx.doi.org/10.1016/j.isci.2023.108351

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