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Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer

A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography. But pure solid T1 lung cancer with ≤3 cm in the greatest dimension is not always at an early stage, despite its small s...

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Autores principales: Mu, Junhao, Huang, Jing, Ao, Min, Li, Weiyi, Jiang, Li, Yang, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680022/
https://www.ncbi.nlm.nih.gov/pubmed/38025970
http://dx.doi.org/10.1093/pcmedi/pbad020
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author Mu, Junhao
Huang, Jing
Ao, Min
Li, Weiyi
Jiang, Li
Yang, Li
author_facet Mu, Junhao
Huang, Jing
Ao, Min
Li, Weiyi
Jiang, Li
Yang, Li
author_sort Mu, Junhao
collection PubMed
description A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography. But pure solid T1 lung cancer with ≤3 cm in the greatest dimension is not always at an early stage, despite its small size. This type of cancer can be highly aggressive and is associated with pathological involvement, metastasis, postoperative relapse, and even death. However, it is easily misdiagnosed or delay diagnosed in clinics and thus poses a serious threat to human health. The percentage of nodal or extrathoracic metastases has been reported to be >20% in T1 lung cancer. As such, understanding and identifying the aggressive characteristics of pure solid T1 lung cancer is crucial for prevention, diagnosis, and therapeutic strategies, and beneficial to improving the prognosis. With the widespread of lung cancer screening, these highly invasive pure solid T1 lung cancer will become the main advanced lung cancer in future. However, there is limited information regarding precision medicine on how to identify these “early-stage” aggressive lung cancers. To provide clinicians with new insights into early recognition and intervention of the highly invasive pure solid T1 lung cancer, this review summarizes its clinical characteristics, imaging, pathology, gene alterations, immune microenvironment, multi-omics, and current techniques for diagnosis and prediction.
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spelling pubmed-106800222023-08-17 Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer Mu, Junhao Huang, Jing Ao, Min Li, Weiyi Jiang, Li Yang, Li Precis Clin Med Minireview A growing number of early-stage lung cancers presenting as malignant pulmonary nodules have been diagnosed because of the increased adoption of low-dose spiral computed tomography. But pure solid T1 lung cancer with ≤3 cm in the greatest dimension is not always at an early stage, despite its small size. This type of cancer can be highly aggressive and is associated with pathological involvement, metastasis, postoperative relapse, and even death. However, it is easily misdiagnosed or delay diagnosed in clinics and thus poses a serious threat to human health. The percentage of nodal or extrathoracic metastases has been reported to be >20% in T1 lung cancer. As such, understanding and identifying the aggressive characteristics of pure solid T1 lung cancer is crucial for prevention, diagnosis, and therapeutic strategies, and beneficial to improving the prognosis. With the widespread of lung cancer screening, these highly invasive pure solid T1 lung cancer will become the main advanced lung cancer in future. However, there is limited information regarding precision medicine on how to identify these “early-stage” aggressive lung cancers. To provide clinicians with new insights into early recognition and intervention of the highly invasive pure solid T1 lung cancer, this review summarizes its clinical characteristics, imaging, pathology, gene alterations, immune microenvironment, multi-omics, and current techniques for diagnosis and prediction. Oxford University Press 2023-08-17 /pmc/articles/PMC10680022/ /pubmed/38025970 http://dx.doi.org/10.1093/pcmedi/pbad020 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of the West China School of Medicine & West China Hospital of Sichuan University. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Minireview
Mu, Junhao
Huang, Jing
Ao, Min
Li, Weiyi
Jiang, Li
Yang, Li
Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer
title Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer
title_full Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer
title_fullStr Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer
title_full_unstemmed Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer
title_short Advances in diagnosis and prediction for aggression of pure solid T1 lung cancer
title_sort advances in diagnosis and prediction for aggression of pure solid t1 lung cancer
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680022/
https://www.ncbi.nlm.nih.gov/pubmed/38025970
http://dx.doi.org/10.1093/pcmedi/pbad020
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