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Inhibition of Dickkopf-1 enhances the anti-tumor efficacy of sorafenib via inhibition of the PI3K/Akt and Wnt/β-catenin pathways in hepatocellular carcinoma

BACKGROUND: Sorafenib improves the overall survival in patients with advanced hepatocellular carcinoma (HCC). Dickkopf-1 (DKK1) is commonly overexpressed in HCC. In this study, we investigated whether the inhibition of DKK1 enhances the anti-tumor efficacy of sorafenib in HCC. METHODS: HCC cells wer...

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Detalles Bibliográficos
Autores principales:	Seo, Sang Hyun, Cho, Kyung Joo, Park, Hye Jung, Lee, Hye Won, Kim, Beom Kyung, Park, Jun Yong, Kim, Do Young, Ahn, Sang Hoon, Cheon, Jae Hee, Yook, Jong In, Kim, Man-Deuk, Joo, Dong Jin, Kim, Seung Up
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680194/ https://www.ncbi.nlm.nih.gov/pubmed/38012711 http://dx.doi.org/10.1186/s12964-023-01355-2

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