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Frailty is related to serum inflammageing markers: results from the VITAL study

Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Fu...

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Autores principales: van Sleen, Yannick, Shetty, Sudarshan A., van der Heiden, Marieke, Venema, Milou C. A., Gutiérrez-Melo, Nicolas, Toonen, Erik J. M., van Beek, Josine, Buisman, Anne-Marie, van Baarle, Debbie, Sauce, Delphine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680197/
https://www.ncbi.nlm.nih.gov/pubmed/38012652
http://dx.doi.org/10.1186/s12979-023-00391-3
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author van Sleen, Yannick
Shetty, Sudarshan A.
van der Heiden, Marieke
Venema, Milou C. A.
Gutiérrez-Melo, Nicolas
Toonen, Erik J. M.
van Beek, Josine
Buisman, Anne-Marie
van Baarle, Debbie
Sauce, Delphine
author_facet van Sleen, Yannick
Shetty, Sudarshan A.
van der Heiden, Marieke
Venema, Milou C. A.
Gutiérrez-Melo, Nicolas
Toonen, Erik J. M.
van Beek, Josine
Buisman, Anne-Marie
van Baarle, Debbie
Sauce, Delphine
author_sort van Sleen, Yannick
collection PubMed
description Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing). Here, we aimed to associate 29 circulating markers of inflammageing with frailty measures in a prospective cohort study to understand the mechanisms underlying ageing. Frailty measures and inflammageing markers were assessed in 317 participants aged 25–90. We determined four different measures of frailty: the Frailty Index based on 31 deficits, the EQ-5D-3L and two physical domains of the SF-36. Serum/plasma levels of inflammageing markers and CMV/EBV seropositivity were measured using different techniques: Quanterix, Luminex or ELISA. All four measures of frailty strongly correlated with age and BMI. Nineteen biomarkers correlated with age, some in a linear fashion (IL-6, YKL-40), some only in the oldest age brackets (CRP), and some increased at younger ages and then plateaued (CCL2, sIL-6R). After correcting for age, biomarkers, such as IL-6, CRP, IL-1RA, YKL-40 and elastase, were associated with frailty. When corrected for BMI, the number of associations reduced further. In conclusion, inflammageing markers, particularly markers reflecting innate immune activation, are related to frailty. These findings indicate that health decline and the accumulation of deficits with age is accompanied with a low-grade inflammation which can be detected by specific inflammatory markers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12979-023-00391-3.
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spelling pubmed-106801972023-11-27 Frailty is related to serum inflammageing markers: results from the VITAL study van Sleen, Yannick Shetty, Sudarshan A. van der Heiden, Marieke Venema, Milou C. A. Gutiérrez-Melo, Nicolas Toonen, Erik J. M. van Beek, Josine Buisman, Anne-Marie van Baarle, Debbie Sauce, Delphine Immun Ageing Research Frailty describes an age-associated state in individuals with an increased vulnerability and less resilience against adverse outcomes. To score frailty, studies have employed the questionnaires, such as the SF-36 and EQ-5D-3L, or the Frailty Index, a composite score based on deficit accumulation. Furthermore, ageing of the immune system is often accompanied by a state of low-grade inflammation (inflammageing). Here, we aimed to associate 29 circulating markers of inflammageing with frailty measures in a prospective cohort study to understand the mechanisms underlying ageing. Frailty measures and inflammageing markers were assessed in 317 participants aged 25–90. We determined four different measures of frailty: the Frailty Index based on 31 deficits, the EQ-5D-3L and two physical domains of the SF-36. Serum/plasma levels of inflammageing markers and CMV/EBV seropositivity were measured using different techniques: Quanterix, Luminex or ELISA. All four measures of frailty strongly correlated with age and BMI. Nineteen biomarkers correlated with age, some in a linear fashion (IL-6, YKL-40), some only in the oldest age brackets (CRP), and some increased at younger ages and then plateaued (CCL2, sIL-6R). After correcting for age, biomarkers, such as IL-6, CRP, IL-1RA, YKL-40 and elastase, were associated with frailty. When corrected for BMI, the number of associations reduced further. In conclusion, inflammageing markers, particularly markers reflecting innate immune activation, are related to frailty. These findings indicate that health decline and the accumulation of deficits with age is accompanied with a low-grade inflammation which can be detected by specific inflammatory markers. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12979-023-00391-3. BioMed Central 2023-11-27 /pmc/articles/PMC10680197/ /pubmed/38012652 http://dx.doi.org/10.1186/s12979-023-00391-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
van Sleen, Yannick
Shetty, Sudarshan A.
van der Heiden, Marieke
Venema, Milou C. A.
Gutiérrez-Melo, Nicolas
Toonen, Erik J. M.
van Beek, Josine
Buisman, Anne-Marie
van Baarle, Debbie
Sauce, Delphine
Frailty is related to serum inflammageing markers: results from the VITAL study
title Frailty is related to serum inflammageing markers: results from the VITAL study
title_full Frailty is related to serum inflammageing markers: results from the VITAL study
title_fullStr Frailty is related to serum inflammageing markers: results from the VITAL study
title_full_unstemmed Frailty is related to serum inflammageing markers: results from the VITAL study
title_short Frailty is related to serum inflammageing markers: results from the VITAL study
title_sort frailty is related to serum inflammageing markers: results from the vital study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680197/
https://www.ncbi.nlm.nih.gov/pubmed/38012652
http://dx.doi.org/10.1186/s12979-023-00391-3
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