Single-cell multiomics of the human retina reveals hierarchical transcription factor collaboration in mediating cell type-specific effects of genetic variants on gene regulation

BACKGROUND: Systematic characterization of how  genetic variation modulates gene regulation in a cell type-specific context is essential for understanding complex traits. To address this question, we profile gene expression and chromatin accessibility in cells from healthy retinae of 20 human donors...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Cheng, Xuesen, Liang, Qingnan, Owen, Leah A., Lu, Jiaxiong, Zheng, Yiqiao, Wang, Meng, Chen, Shiming, DeAngelis, Margaret M., Li, Yumei, Chen, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680294/
https://www.ncbi.nlm.nih.gov/pubmed/38012720
http://dx.doi.org/10.1186/s13059-023-03111-8

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