Genetic alterations that deregulate RB and PDGFRA signaling pathways drive tumor progression in IDH2-mutant astrocytoma

In IDH-mutant astrocytoma, IDH2 mutation is quite rare and biological mechanisms underlying tumor progression in IDH2-mutant astrocytoma remain elusive. Here, we report a unique case of IDH2 mutant astrocytoma, CNS WHO grade 3 that developed tumor progression. We performed a comprehensive genomic an...

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Detalles Bibliográficos
Autores principales: Tateishi, Kensuke, Miyake, Yohei, Nakamura, Taishi, Iwashita, Hiromichi, Hayashi, Takahiro, Oshima, Akito, Honma, Hirokuni, Hayashi, Hiroaki, Sugino, Kyoka, Kato, Miyui, Satomi, Kaishi, Fujii, Satoshi, Komori, Takashi, Yamamoto, Tetsuya, Cahill, Daniel P., Wakimoto, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680361/
https://www.ncbi.nlm.nih.gov/pubmed/38012788
http://dx.doi.org/10.1186/s40478-023-01683-x

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