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Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions

Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced GTPase that inhibits human immunodeficiency virus-1 (HIV-1) infection by preventing nuclear import of the viral preintegration complex. The HIV-1 capsid (CA) is the major viral determinant for sensitivity to MX2, and complex interaction...

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Detalles Bibliográficos
Autores principales:	Layish, Bailey, Goli, Ram, Flick, Haley, Huang, Szu-Wei, Zhang, Robert Z., Kvaratskhelia, Mamuka, Kane, Melissa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680775/ https://www.ncbi.nlm.nih.gov/pubmed/38014352 http://dx.doi.org/10.1101/2023.11.16.567336

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