Noncanonical Activity of Med4 as a Gatekeeper of Metastasis through Epigenetic Control of Integrin Signaling

Breast cancer metastatic relapse after a latency period, known as metastatic dormancy. Through genetic screening in mice, we identified the mediator complex subunit 4 (Med4) as a novel tumor-cell intrinsic gatekeeper in metastatic reactivation. Med4 downregulation effectively awakened dormant breast...

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Detalles Bibliográficos
Autores principales: Bae, Seong-Yeon, Chen, Yi, Chen, Hong, Kumar, Dhiraj, Karaiskos, Spyros, Xu, Jane, Lu, Chao, Viny, Aaron D., Giancotti, Filippo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680920/
https://www.ncbi.nlm.nih.gov/pubmed/38014033
http://dx.doi.org/10.1101/2023.11.18.566087

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