Influence of Point Mutations on PR65 Conformational Adaptability: Insights from Nanoaperture Optical Tweezer Experiments and Molecular Simulations

PR65 is the HEAT-repeat scaffold subunit of the heterotrimeric protein phosphatase 2A (PP2A) and an archetypal tandem-repeat protein, forming a spring-like architecture. PR65 conformational mechanics play a crucial role in PP2A function by opening/closing the substrate-binding/catalysis interface. U...

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Detalles Bibliográficos
Autores principales: Bahar, Ivet, Banerjee, Anupam, Mathew, Samuel, Naqvi, Mohsin, Yilmaz, Sema, Zachoropoulou, Maria, Doruker, Pemra, Kumita, Janet, Yang, Shang-Hua, Gur, Mert, Itzhaki, Laura, Gordon, Reuven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10680943/
https://www.ncbi.nlm.nih.gov/pubmed/38014259
http://dx.doi.org/10.21203/rs.3.rs-3599809/v1

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