Targeted Degradation of XIAP is Sufficient and Specific to Induce Apoptosis in MYCN-overexpressing High-risk Neuroblastoma

XIAP, the most potent mammalian inhibitor of apoptosis protein (IAP), critically restricts developmental culling of sympathetic neuronal progenitors, and is correspondingly overexpressed in most MYCN-amplified neuroblastoma tumors. Because apoptosis-related protein in the TGFβ signaling pathway (ART...

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Detalles Bibliográficos
Autores principales: Choo, Zhang'E, Koh, Xiaoying, Wong, Megan Rui En, Ashokan, Ruth Minothini, Ali Ahamed, Nurul Suhana Binte, Kang, CongBao, Kuick, Chik Hong, Chang, Kenneth Tou En, Larisch, Sarit, Loh, Amos Hong Pheng, Chen, Zhi Xiong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681007/
https://www.ncbi.nlm.nih.gov/pubmed/37874199
http://dx.doi.org/10.1158/2767-9764.CRC-23-0082

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