ECDD-S16 targets vacuolar ATPase: A potential inhibitor compound for pyroptosis-induced inflammation

BACKGROUND: Cleistanthin A (CA), extracted from Phyllanthus taxodiifolius Beille, was previously reported as a potential V-ATPase inhibitor relevant to cancer cell survival. In the present study, ECDD-S16, a derivative of cleistanthin A, was investigated and found to interfere with pyroptosis induct...

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Detalles Bibliográficos
Autores principales: Ekchariyawat, Peeraya, Saengfak, Rattatammanoon, Sanongkiet, Sucharat, Charoenwongpaiboon, Thanapon, Khongpraphan, Suphasuta, Mala, Supaporn, Luangjindarat, Chularat, Munyoo, Bumrung, Chabang, Napason, Charoensutthivarakul, Sitthivut, Borwornpinyo, Suparerk, Tuchinda, Patoomratana, Ponpuak, Marisa, Pudla, Matsayapan, Utaisincharoen, Pongsak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681236/
https://www.ncbi.nlm.nih.gov/pubmed/38011122
http://dx.doi.org/10.1371/journal.pone.0292340

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