Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice

Benznidazole is the front-line drug used to treat infections with Trypanosoma cruzi, the causative agent of Chagas disease. However, for reasons that are unknown, treatment failures are common. When we examined parasites that survived benznidazole treatment in mice using highly sensitive in vivo and...

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Detalles Bibliográficos
Autores principales: Jayawardhana, Shiromani, Ward, Alexander I., Francisco, Amanda F., Lewis, Michael D., Taylor, Martin C., Kelly, John M., Olmo, Francisco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681306/
https://www.ncbi.nlm.nih.gov/pubmed/37956215
http://dx.doi.org/10.1371/journal.ppat.1011627

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