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SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by impairing TRIM4-mediated K63-linked polyubiquitination

Melanoma differentiation-associated gene-5 (MDA5) acts as a cytoplasmic RNA sensor to detect viral dsRNA and mediates antiviral innate immune responses to infection by RNA viruses. Upon recognition of viral dsRNA, MDA5 is activated with K63-linked polyubiquitination and then triggers the recruitment...

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Detalles Bibliográficos
Autores principales:	Zhang, Xiaolin, Yang, Ziwei, Pan, Ting, Sun, Qinqin, Chen, Qingyang, Wang, Pei-Hui, Li, Xiaojuan, Kuang, Ersheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681309/ https://www.ncbi.nlm.nih.gov/pubmed/37956198 http://dx.doi.org/10.1371/journal.ppat.1011792

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