Cargando…

SARS-CoV-2 Nsp8 suppresses MDA5 antiviral immune responses by impairing TRIM4-mediated K63-linked polyubiquitination

Melanoma differentiation-associated gene-5 (MDA5) acts as a cytoplasmic RNA sensor to detect viral dsRNA and mediates antiviral innate immune responses to infection by RNA viruses. Upon recognition of viral dsRNA, MDA5 is activated with K63-linked polyubiquitination and then triggers the recruitment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Xiaolin, Yang, Ziwei, Pan, Ting, Sun, Qinqin, Chen, Qingyang, Wang, Pei-Hui, Li, Xiaojuan, Kuang, Ersheng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681309/ https://www.ncbi.nlm.nih.gov/pubmed/37956198 http://dx.doi.org/10.1371/journal.ppat.1011792

Ejemplares similares

RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination
por: Yang, Ziwei, et al.
Publicado: (2021)

Correction: RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination
por: Yang, Ziwei, et al.
Publicado: (2021)

TRIM15 and CYLD regulate ERK activation via lysine 63-linked polyubiquitination
por: Zhu, Guixin, et al.
Publicado: (2021)

ARRDC4 regulates enterovirus 71-induced innate immune response by promoting K63 polyubiquitination of MDA5 through TRIM65
por: Meng, Jun, et al.
Publicado: (2017)

The role of K63‐linked polyubiquitination in cardiac hypertrophy
por: Yan, Kaowen, et al.
Publicado: (2018)

USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
por: Hou, Jinxiu, et al.
Publicado: (2021)

Regulation of RIG-I Activation by K63-Linked Polyubiquitination
por: Okamoto, Masaaki, et al.
Publicado: (2018)

Suppression of KSHV lytic replication and primary effusion lymphoma by selective RNF5 inhibition
por: Li, Xiaojuan, et al.
Publicado: (2023)

TRIM24 facilitates antiviral immunity through mediating K63-linked TRAF3 ubiquitination
por: Zhu, Qingchen, et al.
Publicado: (2020)

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains
por: Di Rienzo, M., et al.
Publicado: (2019)

TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination
por: Wang, Xiaoyan, et al.
Publicado: (2022)

TRIM31 facilitates K27-linked polyubiquitination of SYK to regulate antifungal immunity
por: Wang, Xueer, et al.
Publicado: (2021)

TRIM41 is required to innate antiviral response by polyubiquitinating BCL10 and recruiting NEMO
por: Yu, Zhou, et al.
Publicado: (2021)

The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5
por: Bu, Lang, et al.
Publicado: (2020)

TRIM67 alleviates cerebral ischemia‒reperfusion injury by protecting neurons and inhibiting neuroinflammation via targeting IκBα for K63-linked polyubiquitination
por: Yu, Yongbo, et al.
Publicado: (2023)

Avid interactions underlie the K63-linked polyubiquitin binding specificities observed for UBA domains
por: Sims, Joshua J., et al.
Publicado: (2009)

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses
por: Oshiumi, Hiroyuki, et al.
Publicado: (2013)

K63 polyubiquitination is a new modulator of the oxidative stress response
por: Silva, Gustavo M., et al.
Publicado: (2015)

Lys63-linked polyubiquitination of BRAF at lysine 578 is required for BRAF-mediated signaling
por: An, Lei, et al.
Publicado: (2013)

TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination
por: Zhu, Xuefei, et al.
Publicado: (2022)

TRIM28 negatively regulates the RLR signaling pathway by targeting MAVS for degradation via K48-linked polyubiquitination
por: Chen, Ya-Yun, et al.
Publicado: (2023)

Porcine Deltacoronavirus Nucleocapsid Protein Suppressed IFN-β Production by Interfering Porcine RIG-I dsRNA-Binding and K63-Linked Polyubiquitination
por: Likai, Ji, et al.
Publicado: (2019)

The ubiquitin ligase HERC4 suppresses MafA transcriptional activity triggered by GSK3β in myeloma by atypical K63-linked polyubiquitination
por: Zhang, Zubin, et al.
Publicado: (2023)

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3
por: Wang, Peng, et al.
Publicado: (2015)

Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
por: Olzmann, James A., et al.
Publicado: (2007)

Rice UBC13, a candidate housekeeping gene, is required for K63-linked polyubiquitination and tolerance to DNA damage
por: Zang, Yuepeng, et al.
Publicado: (2012)

FBXO42 facilitates Notch signaling activation and global chromatin relaxation by promoting K63-linked polyubiquitination of RBPJ
por: Jiang, Hua, et al.
Publicado: (2022)

Ubiquitin-specific protease 24 promotes EV71 infection by restricting K63-linked polyubiquitination of TBK1
por: Zang, Lichao, et al.
Publicado: (2022)

Systematic characterization of Brassica napus UBC13 genes involved in DNA-damage response and K63-linked polyubiquitination
por: Kumasaruge, Ivanthi, et al.
Publicado: (2023)

TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity
por: Lang, Xueting, et al.
Publicado: (2017)

Structural insights into two distinct binding modules for Lys63-linked polyubiquitin chains in RNF168
por: Takahashi, Tomio S., et al.
Publicado: (2018)

Characterization of four rice UEV1 genes required for Lys63-linked polyubiquitination and distinct functions
por: Wang, Qian, et al.
Publicado: (2017)

Paeoniflorin Inhibits EMT and Angiogenesis in Human Glioblastoma via K63-Linked C-Met Polyubiquitination-Dependent Autophagic Degradation
por: Liu, Zhi, et al.
Publicado: (2022)

Lysine 63-Polyubiquitination Guards against Translesion Synthesis–Induced Mutations
por: Chiu, Roland K, et al.
Publicado: (2006)

The E3 ligase TRIM26 suppresses ferroptosis through catalyzing K63-linked ubiquitination of GPX4 in glioma
por: Wang, Zhangjie, et al.
Publicado: (2023)

XIAP upregulates expression of HIF target genes by targeting HIF1α for Lys(63)-linked polyubiquitination
por: Park, Catherine V., et al.
Publicado: (2017)

Inhibiting K63 Polyubiquitination Abolishes No-Go Type Stalled Translation Surveillance in Saccharomyces cerevisiae
por: Saito, Kazuki, et al.
Publicado: (2015)

EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma
por: Li, Boheng, et al.
Publicado: (2023)

NOD2 Down-Regulates Colonic Inflammation by IRF4-Mediated Inhibition of K63-Linked Polyubiquitination of RICK and TRAF6
por: Watanabe, Tomohiro, et al.
Publicado: (2014)

The HECTD3 E3 ubiquitin ligase facilitates cancer cell survival by promoting K63-linked polyubiquitination of caspase-8
por: Li, Y, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_kqa8u77tuur017i68l3tj4hrue