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Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial

INTRODUCTION: In this clinical trial, we investigated the efficacy of two treatment methods for keloids resulting from surgical incisions: intralesional triamcinolone injections alone versus in combination with verapamil. MATERIAL AND METHODS: Patients were divided into two groups: one received tria...

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Autores principales: Haghani‐Dogahe, Zahra, Hadadi, Ramin, Esmailzadeh, Mojdeh, Mobayen, Mohammadreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681400/
https://www.ncbi.nlm.nih.gov/pubmed/37670475
http://dx.doi.org/10.1111/iwj.14314
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author Haghani‐Dogahe, Zahra
Hadadi, Ramin
Esmailzadeh, Mojdeh
Mobayen, Mohammadreza
author_facet Haghani‐Dogahe, Zahra
Hadadi, Ramin
Esmailzadeh, Mojdeh
Mobayen, Mohammadreza
author_sort Haghani‐Dogahe, Zahra
collection PubMed
description INTRODUCTION: In this clinical trial, we investigated the efficacy of two treatment methods for keloids resulting from surgical incisions: intralesional triamcinolone injections alone versus in combination with verapamil. MATERIAL AND METHODS: Patients were divided into two groups: one received triamcinolone alone (Group T) and the other received a triamcinolone‐verapamil blend (Group VT). Regular treatments were conducted until the keloids were nearly flat or for a maximum of eight sessions. RESULTS: Both groups showed significant improvements, but Group VT saw quicker resolution of skin redness and needed fewer sessions. Though the Vancouver Scar Scale (VSS) scores were generally similar across both groups, Group VT exhibited greater improvements, leading to lower final scores. The VT group also attained normal scar flexibility faster than the T group. CONCLUSION: These findings suggest that the combination of verapamil and triamcinolone provides a more effective treatment for keloids, thereby highlighting the potential of verapamil in scar reduction.
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spelling pubmed-106814002023-09-05 Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial Haghani‐Dogahe, Zahra Hadadi, Ramin Esmailzadeh, Mojdeh Mobayen, Mohammadreza Int Wound J Original Articles INTRODUCTION: In this clinical trial, we investigated the efficacy of two treatment methods for keloids resulting from surgical incisions: intralesional triamcinolone injections alone versus in combination with verapamil. MATERIAL AND METHODS: Patients were divided into two groups: one received triamcinolone alone (Group T) and the other received a triamcinolone‐verapamil blend (Group VT). Regular treatments were conducted until the keloids were nearly flat or for a maximum of eight sessions. RESULTS: Both groups showed significant improvements, but Group VT saw quicker resolution of skin redness and needed fewer sessions. Though the Vancouver Scar Scale (VSS) scores were generally similar across both groups, Group VT exhibited greater improvements, leading to lower final scores. The VT group also attained normal scar flexibility faster than the T group. CONCLUSION: These findings suggest that the combination of verapamil and triamcinolone provides a more effective treatment for keloids, thereby highlighting the potential of verapamil in scar reduction. Blackwell Publishing Ltd 2023-09-05 /pmc/articles/PMC10681400/ /pubmed/37670475 http://dx.doi.org/10.1111/iwj.14314 Text en © 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Articles
Haghani‐Dogahe, Zahra
Hadadi, Ramin
Esmailzadeh, Mojdeh
Mobayen, Mohammadreza
Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial
title Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial
title_full Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial
title_fullStr Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial
title_full_unstemmed Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial
title_short Comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: A single‐blinded randomised clinical trial
title_sort comparing intralesional triamcinolone and verapamil‐triamcinolone injections in keloids: a single‐blinded randomised clinical trial
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681400/
https://www.ncbi.nlm.nih.gov/pubmed/37670475
http://dx.doi.org/10.1111/iwj.14314
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