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Comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: A large population-based study
Currently, little knowledge about the survival of early-onset gastric cancer and little evidence about the difference of survival based on Lauren type has been reported. In order to investigate the difference, we conducted a retrospective study using the Surveillance, Epidemiology, and End Results (...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681446/ https://www.ncbi.nlm.nih.gov/pubmed/38013337 http://dx.doi.org/10.1097/MD.0000000000036261 |
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author | Wang, Qiang Wang, Tian |
author_facet | Wang, Qiang Wang, Tian |
author_sort | Wang, Qiang |
collection | PubMed |
description | Currently, little knowledge about the survival of early-onset gastric cancer and little evidence about the difference of survival based on Lauren type has been reported. In order to investigate the difference, we conducted a retrospective study using the Surveillance, Epidemiology, and End Results (SEER) database and compared it comprehensively. SEER database was used to extracted patients and multiple imputation was utilized to fill blank data. Multivariate cox regression analysis and competing risk model were used to identify the risk factors of survival. K-M survival curve and propensity score matching (PSM) was applied to compare the difference of survival of patients based on Lauren type. Totally, we extracted 3932 EOGC patients including 2086 diffused type and 1846 intestinal type. K-M survival curve showed patients aged 20 to 29 had worse survival compared to patients aged at 30 to 45 years. The survival of EOGC patients would be greatly improved after surgery. Multivariate cox regression analysis revealed diffused type was an independent risk factor, as well as T stage, lymph node metastasis, tumor size (>5 cm) and metastasis, while surgery treatment and examined lymph nodes were protective factors. Multivariate competing risk regression model also showed diffused type was risk factor. We performed PSM by matching 1433 diffused EOGC with 1433 intestinal EOGC patients, finding patients with diffused type had a poorer survival. our results revealed that compared to diffused type EOGC, intestinal type was characterized by a better survival. EOGC should be attached more attention by clinicians. |
format | Online Article Text |
id | pubmed-10681446 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-106814462023-11-24 Comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: A large population-based study Wang, Qiang Wang, Tian Medicine (Baltimore) 4500 Currently, little knowledge about the survival of early-onset gastric cancer and little evidence about the difference of survival based on Lauren type has been reported. In order to investigate the difference, we conducted a retrospective study using the Surveillance, Epidemiology, and End Results (SEER) database and compared it comprehensively. SEER database was used to extracted patients and multiple imputation was utilized to fill blank data. Multivariate cox regression analysis and competing risk model were used to identify the risk factors of survival. K-M survival curve and propensity score matching (PSM) was applied to compare the difference of survival of patients based on Lauren type. Totally, we extracted 3932 EOGC patients including 2086 diffused type and 1846 intestinal type. K-M survival curve showed patients aged 20 to 29 had worse survival compared to patients aged at 30 to 45 years. The survival of EOGC patients would be greatly improved after surgery. Multivariate cox regression analysis revealed diffused type was an independent risk factor, as well as T stage, lymph node metastasis, tumor size (>5 cm) and metastasis, while surgery treatment and examined lymph nodes were protective factors. Multivariate competing risk regression model also showed diffused type was risk factor. We performed PSM by matching 1433 diffused EOGC with 1433 intestinal EOGC patients, finding patients with diffused type had a poorer survival. our results revealed that compared to diffused type EOGC, intestinal type was characterized by a better survival. EOGC should be attached more attention by clinicians. Lippincott Williams & Wilkins 2023-11-24 /pmc/articles/PMC10681446/ /pubmed/38013337 http://dx.doi.org/10.1097/MD.0000000000036261 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | 4500 Wang, Qiang Wang, Tian Comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: A large population-based study |
title | Comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: A large population-based study |
title_full | Comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: A large population-based study |
title_fullStr | Comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: A large population-based study |
title_full_unstemmed | Comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: A large population-based study |
title_short | Comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: A large population-based study |
title_sort | comparison of survival between diffuse type and intestinal type early-onset gastric cancer patients: a large population-based study |
topic | 4500 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681446/ https://www.ncbi.nlm.nih.gov/pubmed/38013337 http://dx.doi.org/10.1097/MD.0000000000036261 |
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