Model‐informed drug development of autologous CAR‐T cell therapy: Strategies to optimize CAR‐T cell exposure leveraging cell kinetic/dynamic modeling

Autologous Chimeric antigen receptor (CAR‐T) cell therapy has been highly successful in the treatment of aggressive hematological malignancies and is also being evaluated for the treatment of solid tumors as well as other therapeutic areas. A challenge, however, is that up to 60% of patients do not...

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Detalles Bibliográficos
Autores principales: Mc Laughlin, Anna M., Milligan, Peter A., Yee, Cassian, Bergstrand, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681459/
https://www.ncbi.nlm.nih.gov/pubmed/37448343
http://dx.doi.org/10.1002/psp4.13011

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