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Predilection sites of pyoderma gangrenosum: Retrospective study of 170 clearly diagnosed patients

Pyoderma gangrenosum (PG) is a non‐infectious, neutrophilic dermatosis that was difficult to diagnose in clinical practice. Today, the PARACELSUS score is a validated tool for diagnostics. Based on this score, patients with clearly diagnosed PG were examined with regard to predilection sites. In thi...

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Autores principales: Moelleken, Maurice, Erfurt‐Berge, Cornelia, Ronicke, Moritz, Busch, Dorothee, Hübner, Ursula Hertha, Hüsers, Jens, Przysucha, Mareike, Dissemond, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681478/
https://www.ncbi.nlm.nih.gov/pubmed/37528508
http://dx.doi.org/10.1111/iwj.14323
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author Moelleken, Maurice
Erfurt‐Berge, Cornelia
Ronicke, Moritz
Busch, Dorothee
Hübner, Ursula Hertha
Hüsers, Jens
Przysucha, Mareike
Dissemond, Joachim
author_facet Moelleken, Maurice
Erfurt‐Berge, Cornelia
Ronicke, Moritz
Busch, Dorothee
Hübner, Ursula Hertha
Hüsers, Jens
Przysucha, Mareike
Dissemond, Joachim
author_sort Moelleken, Maurice
collection PubMed
description Pyoderma gangrenosum (PG) is a non‐infectious, neutrophilic dermatosis that was difficult to diagnose in clinical practice. Today, the PARACELSUS score is a validated tool for diagnostics. Based on this score, patients with clearly diagnosed PG were examined with regard to predilection sites. In this retrospective study, the data of patients from the University Hospitals of Essen and Erlangen were analysed in whom the diagnosis of PG could be clearly confirmed using the PARACELSUS score. A total of 170 patients, 49 men (29%) and 121 women (71%) with an average age at first manifestation of 55.5 years, could be included in the analysis. The predilection sites were identified as the lower legs in 80.6% of the patients and the extensor sides in 75.2%. Other localisations of PG were the thighs in 14.1%, mammae and abdomen in 10.0% each, back and gluteal in 7.1% each, feet in 5.9%, arms in 4.7%, genital in 3.5% and head in 2.9%. This retrospective study is the first to identify a collective of PG patients with the highest data quality using the PARACELSUS score. It could be shown that PG can basically occur on the entire integument. However, the predilection sites of PG, which have now been reliably identified for the first time, are the lower legs and in particular the extensor sides.
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spelling pubmed-106814782023-08-01 Predilection sites of pyoderma gangrenosum: Retrospective study of 170 clearly diagnosed patients Moelleken, Maurice Erfurt‐Berge, Cornelia Ronicke, Moritz Busch, Dorothee Hübner, Ursula Hertha Hüsers, Jens Przysucha, Mareike Dissemond, Joachim Int Wound J Original Articles Pyoderma gangrenosum (PG) is a non‐infectious, neutrophilic dermatosis that was difficult to diagnose in clinical practice. Today, the PARACELSUS score is a validated tool for diagnostics. Based on this score, patients with clearly diagnosed PG were examined with regard to predilection sites. In this retrospective study, the data of patients from the University Hospitals of Essen and Erlangen were analysed in whom the diagnosis of PG could be clearly confirmed using the PARACELSUS score. A total of 170 patients, 49 men (29%) and 121 women (71%) with an average age at first manifestation of 55.5 years, could be included in the analysis. The predilection sites were identified as the lower legs in 80.6% of the patients and the extensor sides in 75.2%. Other localisations of PG were the thighs in 14.1%, mammae and abdomen in 10.0% each, back and gluteal in 7.1% each, feet in 5.9%, arms in 4.7%, genital in 3.5% and head in 2.9%. This retrospective study is the first to identify a collective of PG patients with the highest data quality using the PARACELSUS score. It could be shown that PG can basically occur on the entire integument. However, the predilection sites of PG, which have now been reliably identified for the first time, are the lower legs and in particular the extensor sides. Blackwell Publishing Ltd 2023-08-01 /pmc/articles/PMC10681478/ /pubmed/37528508 http://dx.doi.org/10.1111/iwj.14323 Text en © 2023 The Authors. International Wound Journal published by Medicalhelplines.com Inc and John Wiley & Sons Ltd. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Moelleken, Maurice
Erfurt‐Berge, Cornelia
Ronicke, Moritz
Busch, Dorothee
Hübner, Ursula Hertha
Hüsers, Jens
Przysucha, Mareike
Dissemond, Joachim
Predilection sites of pyoderma gangrenosum: Retrospective study of 170 clearly diagnosed patients
title Predilection sites of pyoderma gangrenosum: Retrospective study of 170 clearly diagnosed patients
title_full Predilection sites of pyoderma gangrenosum: Retrospective study of 170 clearly diagnosed patients
title_fullStr Predilection sites of pyoderma gangrenosum: Retrospective study of 170 clearly diagnosed patients
title_full_unstemmed Predilection sites of pyoderma gangrenosum: Retrospective study of 170 clearly diagnosed patients
title_short Predilection sites of pyoderma gangrenosum: Retrospective study of 170 clearly diagnosed patients
title_sort predilection sites of pyoderma gangrenosum: retrospective study of 170 clearly diagnosed patients
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681478/
https://www.ncbi.nlm.nih.gov/pubmed/37528508
http://dx.doi.org/10.1111/iwj.14323
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