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Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review
Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness. It arises from emphysema and chronic bronchitis and is characterized by progressive and irreversible airflow limitation and chronic inflammation of the lungs, which eventually progresses to pulmonary hypertension,...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681501/ https://www.ncbi.nlm.nih.gov/pubmed/38013266 http://dx.doi.org/10.1097/MD.0000000000036390 |
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author | Wang, Qianxinhong Su, Wenlong Liu, Junnan Zhao, Dongkai |
author_facet | Wang, Qianxinhong Su, Wenlong Liu, Junnan Zhao, Dongkai |
author_sort | Wang, Qianxinhong |
collection | PubMed |
description | Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness. It arises from emphysema and chronic bronchitis and is characterized by progressive and irreversible airflow limitation and chronic inflammation of the lungs, which eventually progresses to pulmonary hypertension, chronic pulmonary heart disease and respiratory failure. Autophagy is a highly conserved cellular homeostasis maintenance mechanism that involves the transport of damaged organelles and proteins to lysosomes for destruction. Dysregulation of autophagy is one of the pathogenic mechanisms of many diseases and is strongly associated with the development of COPD, although the precise mechanisms are unknown. In this paper, we focus on macroautophagy, a type of autophagy that has been thoroughly studied, and describe the characteristics, processes, regulatory pathways, and functions of autophagy, and discuss its relationship with COPD from the perspectives of inflammation, emphysema, mucus hypersecretion, cilia structure and function, airway remodeling, vascular remodeling, and bacterial infections, with a view to searching for the therapeutic targets of COPD from the perspective of autophagy, which is hoped to be helpful for the clinical treatment. |
format | Online Article Text |
id | pubmed-10681501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-106815012023-11-24 Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review Wang, Qianxinhong Su, Wenlong Liu, Junnan Zhao, Dongkai Medicine (Baltimore) 6700 Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness. It arises from emphysema and chronic bronchitis and is characterized by progressive and irreversible airflow limitation and chronic inflammation of the lungs, which eventually progresses to pulmonary hypertension, chronic pulmonary heart disease and respiratory failure. Autophagy is a highly conserved cellular homeostasis maintenance mechanism that involves the transport of damaged organelles and proteins to lysosomes for destruction. Dysregulation of autophagy is one of the pathogenic mechanisms of many diseases and is strongly associated with the development of COPD, although the precise mechanisms are unknown. In this paper, we focus on macroautophagy, a type of autophagy that has been thoroughly studied, and describe the characteristics, processes, regulatory pathways, and functions of autophagy, and discuss its relationship with COPD from the perspectives of inflammation, emphysema, mucus hypersecretion, cilia structure and function, airway remodeling, vascular remodeling, and bacterial infections, with a view to searching for the therapeutic targets of COPD from the perspective of autophagy, which is hoped to be helpful for the clinical treatment. Lippincott Williams & Wilkins 2023-11-24 /pmc/articles/PMC10681501/ /pubmed/38013266 http://dx.doi.org/10.1097/MD.0000000000036390 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | 6700 Wang, Qianxinhong Su, Wenlong Liu, Junnan Zhao, Dongkai Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review |
title | Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review |
title_full | Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review |
title_fullStr | Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review |
title_full_unstemmed | Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review |
title_short | Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review |
title_sort | advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: a review |
topic | 6700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681501/ https://www.ncbi.nlm.nih.gov/pubmed/38013266 http://dx.doi.org/10.1097/MD.0000000000036390 |
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