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Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review

Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness. It arises from emphysema and chronic bronchitis and is characterized by progressive and irreversible airflow limitation and chronic inflammation of the lungs, which eventually progresses to pulmonary hypertension,...

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Autores principales: Wang, Qianxinhong, Su, Wenlong, Liu, Junnan, Zhao, Dongkai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681501/
https://www.ncbi.nlm.nih.gov/pubmed/38013266
http://dx.doi.org/10.1097/MD.0000000000036390
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author Wang, Qianxinhong
Su, Wenlong
Liu, Junnan
Zhao, Dongkai
author_facet Wang, Qianxinhong
Su, Wenlong
Liu, Junnan
Zhao, Dongkai
author_sort Wang, Qianxinhong
collection PubMed
description Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness. It arises from emphysema and chronic bronchitis and is characterized by progressive and irreversible airflow limitation and chronic inflammation of the lungs, which eventually progresses to pulmonary hypertension, chronic pulmonary heart disease and respiratory failure. Autophagy is a highly conserved cellular homeostasis maintenance mechanism that involves the transport of damaged organelles and proteins to lysosomes for destruction. Dysregulation of autophagy is one of the pathogenic mechanisms of many diseases and is strongly associated with the development of COPD, although the precise mechanisms are unknown. In this paper, we focus on macroautophagy, a type of autophagy that has been thoroughly studied, and describe the characteristics, processes, regulatory pathways, and functions of autophagy, and discuss its relationship with COPD from the perspectives of inflammation, emphysema, mucus hypersecretion, cilia structure and function, airway remodeling, vascular remodeling, and bacterial infections, with a view to searching for the therapeutic targets of COPD from the perspective of autophagy, which is hoped to be helpful for the clinical treatment.
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spelling pubmed-106815012023-11-24 Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review Wang, Qianxinhong Su, Wenlong Liu, Junnan Zhao, Dongkai Medicine (Baltimore) 6700 Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory illness. It arises from emphysema and chronic bronchitis and is characterized by progressive and irreversible airflow limitation and chronic inflammation of the lungs, which eventually progresses to pulmonary hypertension, chronic pulmonary heart disease and respiratory failure. Autophagy is a highly conserved cellular homeostasis maintenance mechanism that involves the transport of damaged organelles and proteins to lysosomes for destruction. Dysregulation of autophagy is one of the pathogenic mechanisms of many diseases and is strongly associated with the development of COPD, although the precise mechanisms are unknown. In this paper, we focus on macroautophagy, a type of autophagy that has been thoroughly studied, and describe the characteristics, processes, regulatory pathways, and functions of autophagy, and discuss its relationship with COPD from the perspectives of inflammation, emphysema, mucus hypersecretion, cilia structure and function, airway remodeling, vascular remodeling, and bacterial infections, with a view to searching for the therapeutic targets of COPD from the perspective of autophagy, which is hoped to be helpful for the clinical treatment. Lippincott Williams & Wilkins 2023-11-24 /pmc/articles/PMC10681501/ /pubmed/38013266 http://dx.doi.org/10.1097/MD.0000000000036390 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle 6700
Wang, Qianxinhong
Su, Wenlong
Liu, Junnan
Zhao, Dongkai
Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review
title Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review
title_full Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review
title_fullStr Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review
title_full_unstemmed Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review
title_short Advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: A review
title_sort advances in the investigation of the role of autophagy in the etiology of chronic obstructive pulmonary disease: a review
topic 6700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681501/
https://www.ncbi.nlm.nih.gov/pubmed/38013266
http://dx.doi.org/10.1097/MD.0000000000036390
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