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Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review

BACKGROUND: Viral pneumonia such as COVID‐19‐associated aspergillosis could increase susceptibility to fungal super‐infections in critically ill patients. METHODS: Here we report a pediatric case of Aspergillus quadrilineatus cerebral infection in a recently diagnosed COVID‐19‐positive patient under...

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Autores principales: Amirizad, Kazem, Ghazanfari, Mona, Javidnia, Javad, Abastabar, Mahdi, Haghi Ashtiani, Mohammad Taghi, Sotoudeh Anvari, Maryam, Fathi, Maryam, Espahbodi, Amirreza, Badali, Hamid, Hedayati, Mohammad Taghi, Haghani, Iman, Seyedmousavi, Seyedmojtaba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681513/
https://www.ncbi.nlm.nih.gov/pubmed/37798858
http://dx.doi.org/10.1002/jcla.24971
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author Amirizad, Kazem
Ghazanfari, Mona
Javidnia, Javad
Abastabar, Mahdi
Haghi Ashtiani, Mohammad Taghi
Sotoudeh Anvari, Maryam
Fathi, Maryam
Espahbodi, Amirreza
Badali, Hamid
Hedayati, Mohammad Taghi
Haghani, Iman
Seyedmousavi, Seyedmojtaba
author_facet Amirizad, Kazem
Ghazanfari, Mona
Javidnia, Javad
Abastabar, Mahdi
Haghi Ashtiani, Mohammad Taghi
Sotoudeh Anvari, Maryam
Fathi, Maryam
Espahbodi, Amirreza
Badali, Hamid
Hedayati, Mohammad Taghi
Haghani, Iman
Seyedmousavi, Seyedmojtaba
author_sort Amirizad, Kazem
collection PubMed
description BACKGROUND: Viral pneumonia such as COVID‐19‐associated aspergillosis could increase susceptibility to fungal super‐infections in critically ill patients. METHODS: Here we report a pediatric case of Aspergillus quadrilineatus cerebral infection in a recently diagnosed COVID‐19‐positive patient underlying acute lymphocytic leukemia. Morphological, molecular methods, and sequencing were used to identify this emerging species. RESULTS: Histopathological examination showed a granulomatous necrotic area containing dichotomously branching septate hyphae indicating a presumptive Aspergillus structure. The species‐level identity of isolate growing on brain biopsy culture was confirmed by PCR sequencing of the β‐tubulin gene as A. quadrilineatus. Using the CLSI M38‐A3 broth microdilution methodology, the in vitro antifungal susceptibility testing demonstrated 0.032 μg/mL MIC for posaconazole, caspofungin, and anidulafungin and 8 μg/mL against amphotericin B. A combination of intravenous liposomal amphotericin B and caspofungin therapy for 8 days did not improve the patient's condition. The patient gradually continued to deteriorate and expired. CONCLUSIONS: This is the first COVID‐19‐associated cerebral aspergillosis due to A. quadrilineatus in a pediatric patient with acute lymphocytic leukemia. However, comprehensive screening studies are highly recommended to evaluate its frequency and antifungal susceptibility profiles. Before being recommended as first‐line therapy in high‐risk patients, more antifungal susceptibility data are needed.
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spelling pubmed-106815132023-10-05 Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review Amirizad, Kazem Ghazanfari, Mona Javidnia, Javad Abastabar, Mahdi Haghi Ashtiani, Mohammad Taghi Sotoudeh Anvari, Maryam Fathi, Maryam Espahbodi, Amirreza Badali, Hamid Hedayati, Mohammad Taghi Haghani, Iman Seyedmousavi, Seyedmojtaba J Clin Lab Anal Case Reports BACKGROUND: Viral pneumonia such as COVID‐19‐associated aspergillosis could increase susceptibility to fungal super‐infections in critically ill patients. METHODS: Here we report a pediatric case of Aspergillus quadrilineatus cerebral infection in a recently diagnosed COVID‐19‐positive patient underlying acute lymphocytic leukemia. Morphological, molecular methods, and sequencing were used to identify this emerging species. RESULTS: Histopathological examination showed a granulomatous necrotic area containing dichotomously branching septate hyphae indicating a presumptive Aspergillus structure. The species‐level identity of isolate growing on brain biopsy culture was confirmed by PCR sequencing of the β‐tubulin gene as A. quadrilineatus. Using the CLSI M38‐A3 broth microdilution methodology, the in vitro antifungal susceptibility testing demonstrated 0.032 μg/mL MIC for posaconazole, caspofungin, and anidulafungin and 8 μg/mL against amphotericin B. A combination of intravenous liposomal amphotericin B and caspofungin therapy for 8 days did not improve the patient's condition. The patient gradually continued to deteriorate and expired. CONCLUSIONS: This is the first COVID‐19‐associated cerebral aspergillosis due to A. quadrilineatus in a pediatric patient with acute lymphocytic leukemia. However, comprehensive screening studies are highly recommended to evaluate its frequency and antifungal susceptibility profiles. Before being recommended as first‐line therapy in high‐risk patients, more antifungal susceptibility data are needed. John Wiley and Sons Inc. 2023-10-05 /pmc/articles/PMC10681513/ /pubmed/37798858 http://dx.doi.org/10.1002/jcla.24971 Text en © 2023 The Authors. Journal of Clinical Laboratory Analysis published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Reports
Amirizad, Kazem
Ghazanfari, Mona
Javidnia, Javad
Abastabar, Mahdi
Haghi Ashtiani, Mohammad Taghi
Sotoudeh Anvari, Maryam
Fathi, Maryam
Espahbodi, Amirreza
Badali, Hamid
Hedayati, Mohammad Taghi
Haghani, Iman
Seyedmousavi, Seyedmojtaba
Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review
title Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review
title_full Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review
title_fullStr Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review
title_full_unstemmed Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review
title_short Central nervous system Aspergillus quadrilineatus infection in a COVID‐19 patient, a case report and literature review
title_sort central nervous system aspergillus quadrilineatus infection in a covid‐19 patient, a case report and literature review
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681513/
https://www.ncbi.nlm.nih.gov/pubmed/37798858
http://dx.doi.org/10.1002/jcla.24971
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