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Mechanistically modeling peripheral cytokine dynamics following bispecific dosing in solid tumors
Bispecific antibodies exhibit proven clinical benefit, and many bispecifics are currently in clinical development for oncology. Cytokine release syndrome (CRS) is a common clinical adverse effect observed following CD3‐based bispecific dosing. However, the pathophysiology of CRS is not fully underst...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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John Wiley and Sons Inc.
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681545/ https://www.ncbi.nlm.nih.gov/pubmed/36710368 http://dx.doi.org/10.1002/psp4.12928 |