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T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 110...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681640/ https://www.ncbi.nlm.nih.gov/pubmed/37867465 http://dx.doi.org/10.1002/hbm.26514 |
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author | Rahmani, Farzaneh Brier, Matthew R. Gordon, Brian A. McKay, Nicole Flores, Shaney Keefe, Sarah Hornbeck, Russ Ances, Beau Joseph‐Mathurin, Nelly Xiong, Chengjie Wang, Guoqiao Raji, Cyrus A. Libre‐Guerra, Jorge J. Perrin, Richard J. McDade, Eric Daniels, Alisha Karch, Celeste Day, Gregory S. Brickman, Adam M. Fulham, Michael Jack, Clifford R. la La Fougère, Christian Reischl, Gerald Schofield, Peter R. Oh, Hwamee Levin, Johannes Vöglein, Jonathan Cash, David M. Yakushev, Igor Ikeuchi, Takeshi Klunk, William E. Morris, John C. Bateman, Randall J. Benzinger, Tammie L. S. |
author_facet | Rahmani, Farzaneh Brier, Matthew R. Gordon, Brian A. McKay, Nicole Flores, Shaney Keefe, Sarah Hornbeck, Russ Ances, Beau Joseph‐Mathurin, Nelly Xiong, Chengjie Wang, Guoqiao Raji, Cyrus A. Libre‐Guerra, Jorge J. Perrin, Richard J. McDade, Eric Daniels, Alisha Karch, Celeste Day, Gregory S. Brickman, Adam M. Fulham, Michael Jack, Clifford R. la La Fougère, Christian Reischl, Gerald Schofield, Peter R. Oh, Hwamee Levin, Johannes Vöglein, Jonathan Cash, David M. Yakushev, Igor Ikeuchi, Takeshi Klunk, William E. Morris, John C. Bateman, Randall J. Benzinger, Tammie L. S. |
author_sort | Rahmani, Farzaneh |
collection | PubMed |
description | Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1‐weighted and Fluid attenuated inversion recovery (FLAIR) MR scans. There was an exponential decrease in FLAIR‐μ in mutation carriers and an increase in FLAIR and T1 signal heterogeneity (T1‐σ and FLAIR‐σ) as participants approached the symptom onset in both supramarginal, the right postcentral and right superior temporal gyri as well as both caudate nuclei, putamina, thalami, and amygdalae. After controlling for the effect of regional atrophy, FLAIR‐μ decreased and T1‐σ and FLAIR‐σ increased with increasing amyloid beta and tau deposition in numerous cortical regions. In symptomatic mutation carriers and independent of the effect of regional atrophy, tau pathology demonstrated a stronger relationship with image intensity metrics, compared with amyloid pathology. We propose novel MR imaging intensity‐based metrics using standard clinical T1 and FLAIR images which strongly associates with the progression of pathology in dominantly inherited Alzheimer disease. We suggest that tau pathology may be a key driver of the observed changes in this cohort of patients. |
format | Online Article Text |
id | pubmed-10681640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-106816402023-10-23 T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease Rahmani, Farzaneh Brier, Matthew R. Gordon, Brian A. McKay, Nicole Flores, Shaney Keefe, Sarah Hornbeck, Russ Ances, Beau Joseph‐Mathurin, Nelly Xiong, Chengjie Wang, Guoqiao Raji, Cyrus A. Libre‐Guerra, Jorge J. Perrin, Richard J. McDade, Eric Daniels, Alisha Karch, Celeste Day, Gregory S. Brickman, Adam M. Fulham, Michael Jack, Clifford R. la La Fougère, Christian Reischl, Gerald Schofield, Peter R. Oh, Hwamee Levin, Johannes Vöglein, Jonathan Cash, David M. Yakushev, Igor Ikeuchi, Takeshi Klunk, William E. Morris, John C. Bateman, Randall J. Benzinger, Tammie L. S. Hum Brain Mapp Research Articles Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1‐weighted and Fluid attenuated inversion recovery (FLAIR) MR scans. There was an exponential decrease in FLAIR‐μ in mutation carriers and an increase in FLAIR and T1 signal heterogeneity (T1‐σ and FLAIR‐σ) as participants approached the symptom onset in both supramarginal, the right postcentral and right superior temporal gyri as well as both caudate nuclei, putamina, thalami, and amygdalae. After controlling for the effect of regional atrophy, FLAIR‐μ decreased and T1‐σ and FLAIR‐σ increased with increasing amyloid beta and tau deposition in numerous cortical regions. In symptomatic mutation carriers and independent of the effect of regional atrophy, tau pathology demonstrated a stronger relationship with image intensity metrics, compared with amyloid pathology. We propose novel MR imaging intensity‐based metrics using standard clinical T1 and FLAIR images which strongly associates with the progression of pathology in dominantly inherited Alzheimer disease. We suggest that tau pathology may be a key driver of the observed changes in this cohort of patients. John Wiley & Sons, Inc. 2023-10-23 /pmc/articles/PMC10681640/ /pubmed/37867465 http://dx.doi.org/10.1002/hbm.26514 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Rahmani, Farzaneh Brier, Matthew R. Gordon, Brian A. McKay, Nicole Flores, Shaney Keefe, Sarah Hornbeck, Russ Ances, Beau Joseph‐Mathurin, Nelly Xiong, Chengjie Wang, Guoqiao Raji, Cyrus A. Libre‐Guerra, Jorge J. Perrin, Richard J. McDade, Eric Daniels, Alisha Karch, Celeste Day, Gregory S. Brickman, Adam M. Fulham, Michael Jack, Clifford R. la La Fougère, Christian Reischl, Gerald Schofield, Peter R. Oh, Hwamee Levin, Johannes Vöglein, Jonathan Cash, David M. Yakushev, Igor Ikeuchi, Takeshi Klunk, William E. Morris, John C. Bateman, Randall J. Benzinger, Tammie L. S. T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease |
title |
T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease |
title_full |
T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease |
title_fullStr |
T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease |
title_full_unstemmed |
T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease |
title_short |
T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease |
title_sort | t1 and flair signal intensities are related to tau pathology in dominantly inherited alzheimer disease |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681640/ https://www.ncbi.nlm.nih.gov/pubmed/37867465 http://dx.doi.org/10.1002/hbm.26514 |
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