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T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease

Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 110...

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Autores principales: Rahmani, Farzaneh, Brier, Matthew R., Gordon, Brian A., McKay, Nicole, Flores, Shaney, Keefe, Sarah, Hornbeck, Russ, Ances, Beau, Joseph‐Mathurin, Nelly, Xiong, Chengjie, Wang, Guoqiao, Raji, Cyrus A., Libre‐Guerra, Jorge J., Perrin, Richard J., McDade, Eric, Daniels, Alisha, Karch, Celeste, Day, Gregory S., Brickman, Adam M., Fulham, Michael, Jack, Clifford R., la La Fougère, Christian, Reischl, Gerald, Schofield, Peter R., Oh, Hwamee, Levin, Johannes, Vöglein, Jonathan, Cash, David M., Yakushev, Igor, Ikeuchi, Takeshi, Klunk, William E., Morris, John C., Bateman, Randall J., Benzinger, Tammie L. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681640/
https://www.ncbi.nlm.nih.gov/pubmed/37867465
http://dx.doi.org/10.1002/hbm.26514
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author Rahmani, Farzaneh
Brier, Matthew R.
Gordon, Brian A.
McKay, Nicole
Flores, Shaney
Keefe, Sarah
Hornbeck, Russ
Ances, Beau
Joseph‐Mathurin, Nelly
Xiong, Chengjie
Wang, Guoqiao
Raji, Cyrus A.
Libre‐Guerra, Jorge J.
Perrin, Richard J.
McDade, Eric
Daniels, Alisha
Karch, Celeste
Day, Gregory S.
Brickman, Adam M.
Fulham, Michael
Jack, Clifford R.
la La Fougère, Christian
Reischl, Gerald
Schofield, Peter R.
Oh, Hwamee
Levin, Johannes
Vöglein, Jonathan
Cash, David M.
Yakushev, Igor
Ikeuchi, Takeshi
Klunk, William E.
Morris, John C.
Bateman, Randall J.
Benzinger, Tammie L. S.
author_facet Rahmani, Farzaneh
Brier, Matthew R.
Gordon, Brian A.
McKay, Nicole
Flores, Shaney
Keefe, Sarah
Hornbeck, Russ
Ances, Beau
Joseph‐Mathurin, Nelly
Xiong, Chengjie
Wang, Guoqiao
Raji, Cyrus A.
Libre‐Guerra, Jorge J.
Perrin, Richard J.
McDade, Eric
Daniels, Alisha
Karch, Celeste
Day, Gregory S.
Brickman, Adam M.
Fulham, Michael
Jack, Clifford R.
la La Fougère, Christian
Reischl, Gerald
Schofield, Peter R.
Oh, Hwamee
Levin, Johannes
Vöglein, Jonathan
Cash, David M.
Yakushev, Igor
Ikeuchi, Takeshi
Klunk, William E.
Morris, John C.
Bateman, Randall J.
Benzinger, Tammie L. S.
author_sort Rahmani, Farzaneh
collection PubMed
description Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1‐weighted and Fluid attenuated inversion recovery (FLAIR) MR scans. There was an exponential decrease in FLAIR‐μ in mutation carriers and an increase in FLAIR and T1 signal heterogeneity (T1‐σ and FLAIR‐σ) as participants approached the symptom onset in both supramarginal, the right postcentral and right superior temporal gyri as well as both caudate nuclei, putamina, thalami, and amygdalae. After controlling for the effect of regional atrophy, FLAIR‐μ decreased and T1‐σ and FLAIR‐σ increased with increasing amyloid beta and tau deposition in numerous cortical regions. In symptomatic mutation carriers and independent of the effect of regional atrophy, tau pathology demonstrated a stronger relationship with image intensity metrics, compared with amyloid pathology. We propose novel MR imaging intensity‐based metrics using standard clinical T1 and FLAIR images which strongly associates with the progression of pathology in dominantly inherited Alzheimer disease. We suggest that tau pathology may be a key driver of the observed changes in this cohort of patients.
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spelling pubmed-106816402023-10-23 T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease Rahmani, Farzaneh Brier, Matthew R. Gordon, Brian A. McKay, Nicole Flores, Shaney Keefe, Sarah Hornbeck, Russ Ances, Beau Joseph‐Mathurin, Nelly Xiong, Chengjie Wang, Guoqiao Raji, Cyrus A. Libre‐Guerra, Jorge J. Perrin, Richard J. McDade, Eric Daniels, Alisha Karch, Celeste Day, Gregory S. Brickman, Adam M. Fulham, Michael Jack, Clifford R. la La Fougère, Christian Reischl, Gerald Schofield, Peter R. Oh, Hwamee Levin, Johannes Vöglein, Jonathan Cash, David M. Yakushev, Igor Ikeuchi, Takeshi Klunk, William E. Morris, John C. Bateman, Randall J. Benzinger, Tammie L. S. Hum Brain Mapp Research Articles Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1‐weighted and Fluid attenuated inversion recovery (FLAIR) MR scans. There was an exponential decrease in FLAIR‐μ in mutation carriers and an increase in FLAIR and T1 signal heterogeneity (T1‐σ and FLAIR‐σ) as participants approached the symptom onset in both supramarginal, the right postcentral and right superior temporal gyri as well as both caudate nuclei, putamina, thalami, and amygdalae. After controlling for the effect of regional atrophy, FLAIR‐μ decreased and T1‐σ and FLAIR‐σ increased with increasing amyloid beta and tau deposition in numerous cortical regions. In symptomatic mutation carriers and independent of the effect of regional atrophy, tau pathology demonstrated a stronger relationship with image intensity metrics, compared with amyloid pathology. We propose novel MR imaging intensity‐based metrics using standard clinical T1 and FLAIR images which strongly associates with the progression of pathology in dominantly inherited Alzheimer disease. We suggest that tau pathology may be a key driver of the observed changes in this cohort of patients. John Wiley & Sons, Inc. 2023-10-23 /pmc/articles/PMC10681640/ /pubmed/37867465 http://dx.doi.org/10.1002/hbm.26514 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Rahmani, Farzaneh
Brier, Matthew R.
Gordon, Brian A.
McKay, Nicole
Flores, Shaney
Keefe, Sarah
Hornbeck, Russ
Ances, Beau
Joseph‐Mathurin, Nelly
Xiong, Chengjie
Wang, Guoqiao
Raji, Cyrus A.
Libre‐Guerra, Jorge J.
Perrin, Richard J.
McDade, Eric
Daniels, Alisha
Karch, Celeste
Day, Gregory S.
Brickman, Adam M.
Fulham, Michael
Jack, Clifford R.
la La Fougère, Christian
Reischl, Gerald
Schofield, Peter R.
Oh, Hwamee
Levin, Johannes
Vöglein, Jonathan
Cash, David M.
Yakushev, Igor
Ikeuchi, Takeshi
Klunk, William E.
Morris, John C.
Bateman, Randall J.
Benzinger, Tammie L. S.
T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
title T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
title_full T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
title_fullStr T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
title_full_unstemmed T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
title_short T1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease
title_sort t1 and flair signal intensities are related to tau pathology in dominantly inherited alzheimer disease
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10681640/
https://www.ncbi.nlm.nih.gov/pubmed/37867465
http://dx.doi.org/10.1002/hbm.26514
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